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Chemical Structure| 158984-76-0 Chemical Structure| 158984-76-0

Structure of 158984-76-0

Chemical Structure| 158984-76-0

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Product Details of [ 158984-76-0 ]

CAS No. :158984-76-0
Formula : C13H17NO
M.W : 203.28
SMILES Code : OCC1=CCN(CC2=CC=CC=C2)CC1
MDL No. :MFCD16620244

Safety of [ 158984-76-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 158984-76-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 158984-76-0 ]

[ 158984-76-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13659-23-9 ]
  • [ 158984-76-0 ]
  • [ 1150315-94-8 ]
YieldReaction ConditionsOperation in experiment
74% With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃; for 16.3333h; A: 4- { [(2-bromo-4-chlorophenyl)oxy]methyl} - 1 -(phenylmethyl)- 1 ,2,3,6- tetrahydropyridineTriphenylphosphine (6.9 g, 26.3 mmol) was dissolved in THF (175 niL) and the solution cooled to 0 0C in an ice bath under nitrogen. Diisopropyl azodicarboxylate (5.3 g, 26.2 mmol) was then added dropwise and the mixture stirred at 0 0C for 20 minutes, during which a white ppt was seen to form. <strong>[13659-23-9]2-Bromo-5-chlorophenol</strong> (4.4 g, 21 mmol) was then added as a solid followed by [1 -(phenylmethyl)- 1,2,3, 6- tetrahydro-4-pyridinyl]methanol (4.3 g, 21 mmol). The mixture was allowed to warm to ambient temperature overnight. The reaction was evaporated to a residue after 16 hours and then purified by FCC on the ISCO (0% to 25% EtOAc/Hex). Fractions containing product were concentrated to give a colorless oil (6.14g, 74%). MS (ES) m/e 393.8 [M+H]+.
 

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