157014-35-2|2-Bromo-1-(2-fluoro-4-methoxyphenyl)ethanone| Ambeed

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Quality Control of [ 157014-35-2 ] Purity: 98% SDS Specification

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Product Details of [ 157014-35-2 ]

CAS No. :	157014-35-2
Formula :	C₉H₈BrFO₂
M.W :	247.06
SMILES Code :	COC1=CC=C(C(CBr)=O)C(F)=C1
MDL No. :	MFCD03730100
InChI Key :	OKLFPKDKQYVRNJ-UHFFFAOYSA-N
Pubchem ID :	5119591

Safety of [ 157014-35-2 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H302-H335-H314
Precautionary Statements:	P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P403+P233-P405-P501
Class:	8
UN#:	3261
Packing Group:	Ⅱ

Application In Synthesis of [ 157014-35-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 157014-35-2 ]

[ 157014-35-2 ] Synthesis Path-Downstream 1~35

1
[ 132-54-7 ]
[ 157014-35-2 ]
[ 406214-67-3 ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 8429 - 8431.

2
[ 157014-35-2 ]
[ 4892-02-8 ]
[ 406214-68-4 ]

References: [1]Tetrahedron Letters,2001,vol. 42,p. 8429 - 8431.
[2]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

3
[ 157014-35-2 ]
[ 141582-83-4 ]
[ 1026843-12-8 ]

References: [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 5043 - 5051.

4
[ 2905-82-0 ]
[ 157014-35-2 ]
[ 477594-10-8 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

5
[ 5446-02-6 ]
[ 157014-35-2 ]
[ 477594-09-5 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

6
[ 157014-35-2 ]
[ 153355-46-5 ]
[ 406214-63-9 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

7
[ 157014-35-2 ]
[ 119-36-8 ]
[ 3787-37-9 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

8
[ 157014-35-2 ]
[ 46441-67-2 ]
3-(2-fluoro-4-methoxy-phenyl)-3-hydroxy-1-(4-methoxy-phenyl)-2,5,6,8-tetrahydro-3H-imidazo[2,1-c][1,4]oxazin-1-ium; bromide [ No CAS ]

References: [1]Chemistry of Heterocyclic Compounds,2003,vol. 39,p. 1084 - 1089.

9
[ 157014-35-2 ]
[ 3787-42-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

10
[ 157014-35-2 ]
7-hydroxy-5-oxa-11-thia-benzo[b]fluoren-10-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

11
[ 157014-35-2 ]
3,7-dihydroxy-5,11-dioxa-benzo[b]fluoren-10-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

12
[ 157014-35-2 ]
2,7-dihydroxy-5,11-dioxa-benzo[b]fluoren-10-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

13
[ 157014-35-2 ]
[ 592474-69-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

14
[ 157014-35-2 ]
3,7-dihydroxy-10-oxo-10H-5,11-dioxa-benzo[b]fluorene-1-carbonitrile [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 2399 - 2403.

Yield	Reaction Conditions	Operation in experiment
		The following compounds were synthesised by substantially the same procedure as Reference Example 1. ... 2-Bromo-2'-trifluoromethylacetone, 2-Bromo-3'-(2-methoxyethoxy)acetophenone, 2-(Bromoacetyl)furan, 2-Bromo-3'-fluoro-4'-methoxyacetophenone, 2-Bromo-2'-fluoro-4'-methoxyacetophenone, 2-Bromo-4'-(2-fluoroethoxy)acetophenone, 2-Bromo-3'-(2-fluoroethoxy)acetophenone, 2-Bromo-5'-bromo-2',4'-diethoxypropiophenone, ...
		Typical examples of the halomethyl phenyl ketones (2) wherein X is a bromine atom include 2 -bromoacetophenone, ... 2-bromo-4'-chloro-2'-fluoroacetophenone, 2-bromo-2',4'-difluoroacetophenone, 2-bromo-4'-bromo-2'-fluoroacetophenone, 2-bromo-2'-fluoro-4'-methylacetophenone, 2-bromo-2'-fluoro-4'-methoxyacetophenone, 2-bromo-4'-ethoxy-2'-fluoroacetophenone, 2-bromo-4'-chloro-2'-ethoxyacetophenone, 2-bromo-4'-bromo-2'-ethoxyacetophenone, ...

16
[ 74457-86-6 ]
[ 157014-35-2 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 106 2-Bromo-2'-fluoro-4'-methoxyacetophenone (VI) Following the general procedure of EXAMPLE 100 and making non-critical variations but starting with 2'fluoro-4'-methoxyacetophenone (Aldrich Chemical Co.), the title compound is obtained, mp 67-69; NMR (CDCl3, TMS) 7.95, 6.79, 6.64, 4.48δ; HRMS (EI, m/z) calculated for C9 H8 BrFO2 M+ found=246 and 248.

References: [1]Patent: WO2021/155367,2021,A2 .Location in patent: Page/Page column 104-105.
[2]Journal of Medicinal Chemistry,2012,vol. 55,p. 9607 - 9618.
[3]Patent: US5502187,1996,A .
[4]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 182 - 185.

17
[ 60100-09-6 ]
[ 157014-35-2 ]
[ 1314984-63-8 ]