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Chemical Structure| 1552-41-6 Chemical Structure| 1552-41-6

Structure of 1552-41-6

Chemical Structure| 1552-41-6

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Product Details of [ 1552-41-6 ]

CAS No. :1552-41-6
Formula : C12H16NO3P
M.W : 253.23
SMILES Code : O=P(CC1=CC=C(C#N)C=C1)(OCC)OCC
MDL No. :MFCD08274488
InChI Key :MFXWOYIWKNJHPC-UHFFFAOYSA-N
Pubchem ID :241438

Safety of [ 1552-41-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319
Precautionary Statements:P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 1552-41-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1552-41-6 ]

[ 1552-41-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 33985-71-6 ]
  • [ 1552-41-6 ]
  • [ 228579-67-7 ]
  • 2
  • [ 1552-41-6 ]
  • [ 110677-45-7 ]
  • C27H18N2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium tert-butylate; In tetrahydrofuran; at 20℃; for 4h; A mixture of 3.00 g (1 1.06 mmol) <strong>[110677-45-7]4-(9H-carbazole-9-yl)benzaldehyde</strong> (example 1 .1 ) was react- ed with 2.69 g (10.53 mmol) (4-cyanobenzyl)-phosphonic acid-diethylester, 1.33 g (1 1 .6 mmol) KOtBu and 10OmL of THF at room temperature for 4 hours. (0390) The solvent was removed from the reaction mixture. The residue was worked up with water and ethyl acetate. The insoluble residue in the aqueous layer was filtered, washed with water und dried under reduced pressure. 1 .41 g (36%) of a yellow solid were obtained. (0391) The solvent from the organic phase from the extraction was removed. The residue was mixed with MTBE (Methyl-tert-butylether), filtered and washed with MTBE and n-pentane. The residue was dried under reduced pressure. 1.12 g (29%) of a yellow solid were obtained.
  • 3
  • [ 1552-41-6 ]
  • [ 110677-45-7 ]
  • C27H18N2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With potassium tert-butylate; In N,N-dimethyl-formamide; (1) Weigh 1.0851g (4mmol) of 4-(9H-carbazole)benzaldehyde,0.1683g (1.5mmol) of potassium tert-butoxide, 40mL of dichloromethane,(4-cyanobenzyl) diethyl phosphonate 4mL (4.8mmol) in a 100mL three-necked flask,Use thin layer analysis to track the reaction to the end and add deionized water,Extracted with ethyl acetate 3 times,The organic phases were combined and dried with anhydrous magnesium sulfate for 24 hours,After filtration, it is separated by column chromatography,0.8728 g (2.3 mmol) of a pale yellow solid was obtained with a yield of 58%.
 

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