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Chemical Structure| 1538550-43-4 Chemical Structure| 1538550-43-4

Structure of 1538550-43-4

Chemical Structure| 1538550-43-4

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Product Details of [ 1538550-43-4 ]

CAS No. :1538550-43-4
Formula : C15H13ClN4
M.W : 284.74
SMILES Code : N#C/C=C/C1=CC(C)=C(NC2=NC(Cl)=NC=C2)C(C)=C1

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Application In Synthesis of [ 1538550-43-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1538550-43-4 ]

[ 1538550-43-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1538550-43-4 ]
  • [ 873-74-5 ]
  • [ 500287-72-9 ]
YieldReaction ConditionsOperation in experiment
40 g With toluene-4-sulfonic acid; In isopropyl alcohol; at 20 - 85℃; for 4h; Example 5:Preparation of rilpivirineTo a mixture of (E)-3-( 4-(2-chloropyrimidin-4-ylamino )-3,5-dimethylphenyl)acrylonitrile ( 40 gm), 4-aminobenzonitrile (17 gm), isopropanol ( 400 ml)5 and p-toluenesulfonic acid (20 ml) were added at room temperature. The reaction mixturewas then heated to 80 to 85C and stirred for 4 hours. The reaction mass was then cooledto 0C and pH was adjusted to 10 to 11 with aqueous ammonia solution. The separatedsolid was filtered and then dried to provide 40 gm of rilpivirine.Chromatographic purity: 96.0%;10 Content of Z-isomer: 3.5%.
 

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