Home Cart Sign in  
Chemical Structure| 15366-32-2 Chemical Structure| 15366-32-2

Structure of 15366-32-2

Chemical Structure| 15366-32-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 15366-32-2 ]

CAS No. :15366-32-2
Formula : C6H14ClN3O2
M.W : 195.65
SMILES Code : O=C(OCC)CN(C)C(N)=N.[H]Cl
MDL No. :MFCD08704792
InChI Key :SZZVKHCNEZPXOL-UHFFFAOYSA-N
Pubchem ID :25114309

Safety of [ 15366-32-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Computational Chemistry of [ 15366-32-2 ] Show Less

Physicochemical Properties

Num. heavy atoms 12
Num. arom. heavy atoms 0
Fraction Csp3 0.67
Num. rotatable bonds 5
Num. H-bond acceptors 3.0
Num. H-bond donors 2.0
Molar Refractivity 48.4
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

79.41 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

0.0
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

0.33
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

0.18
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

0.18
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-1.0
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

-0.06

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-0.93
Solubility 22.9 mg/ml ; 0.117 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-1.56
Solubility 5.37 mg/ml ; 0.0275 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-0.21
Solubility 120.0 mg/ml ; 0.614 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

No
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

No
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-7.26 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

1.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

2.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

2.14

Application In Synthesis of [ 15366-32-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15366-32-2 ]

[ 15366-32-2 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 15366-32-2 ]
  • [ 109-89-7 ]
  • [ 71-43-2 ]
  • [ 60-27-5 ]
  • 2
  • [ 64-17-5 ]
  • [ 57-00-1 ]
  • [ 15366-32-2 ]
YieldReaction ConditionsOperation in experiment
89% With phosgene; dmap; at 10℃; for 0.5h;Sealed tube; 1000 g of ethanol was sequentially added to a 2000 mL flask equipped with a stirring device.1.0 g 4-dimethylaminopyridine, 100 g creatine monohydrate, stir and cool to 10 C,Start to add 100g of phosgene (produced by the reaction of concentrated sulfuric acid and carbon tetrachloride, slowly added after low temperature condensation),After the completion of the dropwise addition, the reaction was carried out for 30 minutes. After filtration, it is dried in a hot air oven at 100 C.Obtained 117 g of a white solid (based on anhydrous creatine,The yield was 89%).
73% With chlorophosphonic acid; at 0 - 60℃; for 0.75h; Example 12Ethyl[[[amino](imino)methyl](methyl)amino]acetate (24); Phosphorochloridic acid (2.0-2.5 equivalents to creatine) was added dropwise to a suspension of creatine in 10 mL of ethanol at 0 C. The reaction mixture was stirred for 15 min at 0 C. and the temperature then raised to 60 C. and stirred for 30 min. The reaction mixture was then cooled to provide 1.7 g of the hydrochloride salt of title compound (24) (73% yield) as a white solid. 1H NMR (CD3OD, 400 MHz): delta 4.20-4.30 (m, 4H), 3.16(s, 3H, creatinine NCH3), 3.08 (s, 3H, CBE NCH3), 1.31 (d, J=6.8 Hz), (CBE/creatinine=9:1).
54% at 37℃; for 20h;Acidic conditions;Product distribution / selectivity; Optimization experiments were performed by varying certain parameters of the reaction scheme in Example 1, as described below. A 1.5 mole equivalent of acetyl chloride was added dropwise to anhydrous ethanol to generate the acidified ethanol. Creatine monohydrate was added to the acidified ethanol at a ratio of 1 g:6 ml of ethanol and the reaction medium was heated to 37 C. for 20 hours. The reaction medium was then allowed to cool to 30 C. prior to filtration and the product (filter cake) was washed with ethanol chilled to 0 C. The amount of ethanol used in the wash was on a 1:1 w/v (g/ml) basis with the quantity of creatine monohydrate employed as the starting material. This reaction scheme yielded an 83 to 86% conversion of creatine monohydrate to CEE HCl. [0044] A. Length of Reaction Time [0045] Shortening the reaction time from 20 hours to 10-12 hours resulted in a decrease in the conversion of creatine monohydrate to CEE HCl to about 76 to 83%. Increasing the reaction time to greater than 20 hours resulted in no significant increase in the conversion of creatine monohydrate to CEE HCl. Such longer reaction times, however, did result in the increased formation of the undesirable product creatinine HCl. [0046] B. Temperature at Filtration [0047] After heating the reaction medium to 37 C. for 20 hours, the reaction medium was cooled to various temperatures prior to filtration. The results of these experiments are summarized in Table 1. [TABLE-US-00001] TABLE 1 Temperature Product Product At Filtration Purity Yield 30 C. 99% 54% 25 C. 95% 66% 6 C. 94% 79% [0048] Cooling the filtrate to 6 C. resulted in significantly greater yields compared to either 25 C. or 30 C., but with a relatively slight loss of purity. In each of these experiments, the primary impurity found in the reaction product was creatine HCl. [0049] C. Ratio of Acetyl Chloride to Creatine Monohydrate [0050] The ratio of acetyl chloride to creatine monohydrate was varied to optimize the production of CEE HCl while minimizing the formation of the undesired product creatinine HCl. The amount of acetyl chloride employed was varied between 1.3 and 2.0 mole equivalents and the results of the experiments are summarized in Table 2. [TABLE-US-00002] TABLE 2 Mole equivalents of Product Product acetyl chloride Conversion Purity Yield 1.3 74% 99% 37% 1.4 84% 98% 48% 1.5 83-86% 99% 54% 1.6 86% 99% 57% 2.0 83% 93% 63% [0051] The only impurity present in the final solid reaction product was creatine HCl when 1.3 to 1.6 mole equivalents of acetyl chloride were employed. Creatinine HCl was the only impurity identified when 2.0 equivalents were employed. These results indicate that 1.5 to 1.6 equivalents of acetyl chloride may be optimal as these conditions produced the greatest conversion and yield of the desired product with a high degree of purity. Higher amounts of acetyl chloride, such as greater than 2.0 mole equivalents, are less desirable despite the higher yields because of the greater production of the undesired creatinine HCl reaction byproduct. [0052] D. Composition of Starting Ethanol [0053] The composition of the starting ethanol to which the acetyl chloride is added was varied between a 100:0 and 80:20 ratio (v/v) of ethanol (EtOH) to ethyl acetate (EtOAc). The results of these experiments are presented in Table 3. [TABLE-US-00003] TABLE 3 EtOH:EtOAc Product Product (v/v) Conversion Purity Yield 100:0 83-86% 99% 54% 95:5 88% 96% 65% 90:10 87% 93% 64% 80:20 84% 93% 64% [0054] These data indicate that the 95:5 EtOH:EtOAc ratio (v/v) may be preferred because the increase in yield likely outweighs the slight loss in purity. One notable disadvantage with using larger amounts of EtOAc is that the reaction impurities consisted of about a 3:1 molar ratio of creatinine HCl:creatine HCl. Filtering the reaction mixture at a slightly higher temperature would improve the purity of the isolated CEE HCl, but as noted hereinabove (see part B) such an increase in temperature may result in a concomitant decrease in yield. [0055] Notably, all of the acetyl chloride added to the ethanol is also converted to EtOAc. Therefore the actual ratio of EtOH:EtOAc at the time of creatine monohydrate addition is different than the starting material. [0056] A number of literature and patent references are cited in the foregoing application in order to more fully describe the state of the art to which this invention pertains. The entire disclosure of each of these citations is incorporated by reference herein. [0057] While certain embodiments of the present invention have been described and/or specifically exemplified above, various other embodiments will be apparent to those skilled in the art from the foregoing disclosure. The present invention is, therefore, not limited to such embodiments, but is capable of considerable variation and modification without departing from the scope of the following claims.
With acetyl chloride; In water; at 40℃; A general procedure for the preparation of creatine ethyl ester hydrochloride will now be described. Two ml of anhydrous ethanol is diluted with 67 mul of a 9:1 mixture of ethanol and water and stirred under an Argon atmosphere. To the mixture is added acetyl chloride (164 mul, 2.30 mmol) and the solution stirred for 5 minutes. The solution is heated to 40 degrees C. and creatine (200 mg, 1.53 mmol) is added to the stirring mixture. The mixture is stirred overnight at 40 degrees C. The creatine ethyl ester hydrochloride is recovered by cooling the mixture to 0 degrees C., filtering the white precipitate and washing it with a minimum quantity of cold ethanol. The material can be stored under anhydrous conditions at -15 degrees C.

  • 3
  • [ 15366-32-2 ]
  • by drying heating [ No CAS ]
  • [ 60-27-5 ]
  • 4
  • [ 57-00-1 ]
  • [ 15366-32-2 ]
YieldReaction ConditionsOperation in experiment
48 - 63% With hydrogenchloride; Similar experiments performed with hydrogen chloride introduced directly from a gas cylinder led to yields of CEE HCl of only 48 to 63%.
YieldReaction ConditionsOperation in experiment
Creatine ethyl ester hydrochloride 1H NMR(500 MHz, CDCl3) delta1.12(dq, J=6.0 Hz, J=1.0 Hz, 3H), 2.91, (s,3H), 4.10-4.11 (m, 4H).
  • 6
  • [ 64-17-5 ]
  • [ 57-00-1 ]
  • [ 15366-32-2 ]
  • [ 141-78-6 ]
YieldReaction ConditionsOperation in experiment
80 - 92% Synthesis of Creatine Ethyl Ester Hydrochloride by Acid-Catalyzed Esterification of Creatine Monohyrdate [0039] A 1.5 molar equivalent of acetyl chloride was added dropwise to either anhydrous ethanol protected by a calcium chloride drying tube with constant stirring. The acetyl chloride was added at such a rate so as to prevent the temperature of the acidified solvent from exceeding 60 C. [0040] The temperature of the acidified ethanol was then allowed to decline to about 35 to 40 C. When the acidified ethanol reached the lower temperatures, creatine monohydrate was added in one portion in the ratio of 1 g of creatine monohydrate to 6 to 10 ml of acidified ethanol. The resultant reaction was stirred for 2 to 8 hours at about 40 to 50 C. [0041] The temperature of the reaction mixture was then allowed to cool to about room temperature with constant stirring. White crystalline creatine ethyl ester hydrochloride (CEE HCl) was collected by vacuum filtration and washed with approximately 1 ml of ice cold ethanol per 1 g of CEE HCl product. After the removal of most of the solvent by vacuum filtration, the CEE HCl was removed from the filter and then allowed to dry in a fume hood. [0042] The yield of CEE HCl from this method was 74%, but a total yield of about 80 to 92% (i.e. conversion) is obtainable when the CEE HCl remaining in the filtrate or mother liquor following the initial isolation of CEE HCl is considered. Additionally, the reaction product is 94 to 100% CEE HCl, with any impurities consisting of hydrochlorides of creatine and creatinine.
37 - 79% Optimization experiments were performed by varying certain parameters of the reaction scheme in Example 1, as described below. A 1.5 mole equivalent of acetyl chloride was added dropwise to anhydrous ethanol to generate the acidified ethanol. Creatine monohydrate was added to the acidified ethanol at a ratio of 1 g:6 ml of ethanol and the reaction medium was heated to 37 C. for 20 hours. The reaction medium was then allowed to cool to 30 C. prior to filtration and the product (filter cake) was washed with ethanol chilled to 0 C. The amount of ethanol used in the wash was on a 1:1 w/v (g/ml) basis with the quantity of creatine monohydrate employed as the starting material. This reaction scheme yielded an 83 to 86% conversion of creatine monohydrate to CEE HCl. [0044] A. Length of Reaction Time [0045] Shortening the reaction time from 20 hours to 10-12 hours resulted in a decrease in the conversion of creatine monohydrate to CEE HCl to about 76 to 83%. Increasing the reaction time to greater than 20 hours resulted in no significant increase in the conversion of creatine monohydrate to CEE HCl. Such longer reaction times, however, did result in the increased formation of the undesirable product creatinine HCl. [0046] B. Temperature at Filtration [0047] After heating the reaction medium to 37 C. for 20 hours, the reaction medium was cooled to various temperatures prior to filtration. The results of these experiments are summarized in Table 1. [TABLE-US-00001] TABLE 1 Temperature Product Product At Filtration Purity Yield 30 C. 99% 54% 25 C. 95% 66% 6 C. 94% 79% [0048] Cooling the filtrate to 6 C. resulted in significantly greater yields compared to either 25 C. or 30 C., but with a relatively slight loss of purity. In each of these experiments, the primary impurity found in the reaction product was creatine HCl. [0049] C. Ratio of Acetyl Chloride to Creatine Monohydrate [0050] The ratio of acetyl chloride to creatine monohydrate was varied to optimize the production of CEE HCl while minimizing the formation of the undesired product creatinine HCl. The amount of acetyl chloride employed was varied between 1.3 and 2.0 mole equivalents and the results of the experiments are summarized in Table 2. [TABLE-US-00002] TABLE 2 Mole equivalents of Product Product acetyl chloride Conversion Purity Yield 1.3 74% 99% 37% 1.4 84% 98% 48% 1.5 83-86% 99% 54% 1.6 86% 99% 57% 2.0 83% 93% 63% [0051] The only impurity present in the final solid reaction product was creatine HCl when 1.3 to 1.6 mole equivalents of acetyl chloride were employed. Creatinine HCl was the only impurity identified when 2.0 equivalents were employed. These results indicate that 1.5 to 1.6 equivalents of acetyl chloride may be optimal as these conditions produced the greatest conversion and yield of the desired product with a high degree of purity. Higher amounts of acetyl chloride, such as greater than 2.0 mole equivalents, are less desirable despite the higher yields because of the greater production of the undesired creatinine HCl reaction byproduct. [0052] D. Composition of Starting Ethanol [0053] The composition of the starting ethanol to which the acetyl chloride is added was varied between a 100:0 and 80:20 ratio (v/v) of ethanol (EtOH) to ethyl acetate (EtOAc). The results of these experiments are presented in Table 3. [TABLE-US-00003] TABLE 3 EtOH:EtOAc Product Product (v/v) Conversion Purity Yield 100:0 83-86% 99% 54% 95:5 88% 96% 65% 90:10 87% 93% 64% 80:20 84% 93% 64% [0054] These data indicate that the 95:5 EtOH:EtOAc ratio (v/v) may be preferred because the increase in yield likely outweighs the slight loss in purity. One notable disadvantage with using larger amounts of EtOAc is that the reaction impurities consisted of about a 3:1 molar ratio of creatinine HCl:creatine HCl. Filtering the reaction mixture at a slightly higher temperature would improve the purity of the isolated CEE HCl, but as noted hereinabove (see part B) such an increase in temperature may result in a concomitant decrease in yield. [0055] Notably, all of the acetyl chloride added to the ethanol is also converted to EtOAc. Therefore the actual ratio of EtOH:EtOAc at the time of creatine monohydrate addition is different than the starting material. [0056] A number of literature and patent references are cited in the foregoing application in order to more fully describe the state of the art to which this invention pertains. The entire disclosure of each of these citations is incorporated by reference herein. [0057] While certain embodiments of the present invention have been described and/or specifically exemplified above, various other embodiments will be apparent to those skilled in the art from the foregoing disclosure. The present invention is, therefore, not limited to such embodiments, but is capable of considerable variation and modification without departing from the scope of the following claims.
  • 7
  • [ 60-27-5 ]
  • [ 64-17-5 ]
  • [ 15366-32-2 ]
  • 8
  • [ 128-44-9 ]
  • [ 15366-32-2 ]
  • amino((2-ethoxy-2-oxoethyl)(methyl)amino)methaniminium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
96% In ethanol; at 50℃; for 4h; To the solution of CEE hydrochloride 22 (1 .0 mmol, 195 mg) in EtCH (15 mL)equimolar quantity of sweetener salt (potassium 6-methyl-4-oxo-4H-1 ,2,3-oxathiazin-3-ide2,2-dioxide 0.201 g for 20a and sodium benzo[d]isothiazol-3-olate 1,1-dioxide hydrate 0.205g for 20b) was added and the mixture was then stirred for 4h at the 50 C. Sodium or potassium chloride, formed during the reaction, was separated by filtration through the 22 micron membrane filter and the filtrate was taken to dryness. Diethyl ether was added to the products and after it was evaporated, products 23a and 23b were isolated as white solids in quantitative yields.
  • 9
  • [ 15366-32-2 ]
  • [ 145-42-6 ]
  • amino((2-ethoxy-2-oxoethyl)(methyl)amino)methaniminium 2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% In ethanol; at 50℃; for 4h; To the solution of CEE hydrochloride 22(1.0 mmol, 0.195 g) in EtCH (15 mL) equimolar quantity of sodium taurocholate hydrate 24(1 .0 mmol, 0.538 g) was added and the mixture was then stirred for 4h at the 50 C. Sodium chloride, formed during the reaction, was separated by filtration through the 22 micron membrane filter and the filtrate was taken to dryness. Diethyl ether was added to the product and after evaporation, product 26 was isolated as white solid in quantitative yield.White solid (95%, 0.641 g, 0.95 mmol). M.p. 179.4-195.4 C; 1H NMR (500 MHz,CD3OD, 5)4.27-4.23 (m, 1H), 4.19 (5, 1H), 3.95 (5, 1H), 3.79 (5, 1H), 3.58 (t, J= 7.0 Hz,2H), 3.49 (q, J= 7.0 Hz, 1H), 3.40-3.35 (m, 2H), 3.19 (5, 2H), 3.07 (5, 1H), 2.96 (t, J= 3.0Hz, 2H), 2.31-2.23 (m, 3H), 2.14-2.07 (m, 1H), 2.02-1.92 (m, 2H), 1.90-1.83 (m, 2H), 1.82-1.71 (m, 3H), 1.67-1.61.4 (m, 1H), 1.61-1.51 (m, 5H), 1.43-1.26 (m, 6H), 1.17 (t, J= 7.1, 2H),1.12-1.09 (m, 1H), 1.03 (d, J= 6.1 Hz, 2H), 0.98-0.95 (m, 2H), 0.91 (5, 3H), 0.71 (brs, 3H).l3 NMR (125 MHz, CD3OD) O 177.0, 169.8, 160.0, 74.5, 73.3, 69.5, 63.4, 58.8, 53.1, 52.0,48.5, 48.0, 43.6, 43.5, 41.5, 40.9, 38.4, 37.4, 37.1, 36.4, 34.7, 33.6, 31.7, 30.1, 29.1, 28.3,24.7, 23.7, 18.9, 18.3, 14.9, 13.5. HRMS(ESI) calcd for C6H14N302 [M+H] 160.1081, found160.1080; HRMS (ESI) calcd for C26H44N075 [M-H]- 514.2844, found 514.2830.
  • 10
  • [ 55589-62-3 ]
  • [ 15366-32-2 ]
  • amino((2-ethoxy-2-oxoethyl)(methyl)amino)methaniminium 6-methyl-4-oxo-4H-1,2,3-oxathiazin-3-ide 2,2-dioxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
97% In ethanol; at 50℃; for 4h; To the solution of CEE hydrochloride 22 (1 .0 mmol, 195 mg) in EtCH (15 mL)equimolar quantity of sweetener salt (potassium 6-methyl-4-oxo-4H-1 ,2,3-oxathiazin-3-ide2,2-dioxide 0.201 g for 20a and sodium benzo[d]isothiazol-3-olate 1,1-dioxide hydrate 0.205g for 20b) was added and the mixture was then stirred for 4h at the 50 C. Sodium or potassium chloride, formed during the reaction, was separated by filtration through the 22 micron membrane filter and the filtrate was taken to dryness. Diethyl ether was added to the products and after it was evaporated, products 23a and 23b were isolated as white solids in quantitative yields.White solid (97%, 0.312 g, 0.97 mmol). M.p. 118.9- 122.0 C; 1H NMR (500 MHz, CD3OD, 5)5.56(s, 1H), 4.30-4.24 (m, 4H), 3.11 (5, 3H), 2.09 (5, 3H), 1.33 (t, J= 7.2 Hz, 3H); 13C NMR (125 MHz, CD3OD, 5)173.2, 169.8, 164.4, 160.0, 102.7, 63.4, 53.1, 38.4,20.3, 14.9. HRMS (ESI) calcd for C6H14N302 [M+H] 160.1081, found 160.1079; HRMS (ESI) calcd for C4H4N045 [M-H]- 161 .9867, found 161 .9868.
 

Historical Records

Categories