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Chemical Structure| 153304-75-7 Chemical Structure| 153304-75-7

Structure of 153304-75-7

Chemical Structure| 153304-75-7

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Product Details of [ 153304-75-7 ]

CAS No. :153304-75-7
Formula : C10H13NO2
M.W : 179.22
SMILES Code : O=C(OC)C1=CC=C(N)C(CC)=C1
MDL No. :MFCD00230305
InChI Key :BUHJYJUFJWHZKI-UHFFFAOYSA-N
Pubchem ID :22006574

Safety of [ 153304-75-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 153304-75-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 153304-75-7 ]

[ 153304-75-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 153304-75-7 ]
  • [ 7205-46-1 ]
  • [ 1449669-05-9 ]
YieldReaction ConditionsOperation in experiment
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos; In 1,4-dioxane; at 85.0℃; for 4h; Methyl 4-amino-3-ethylbenzoate (0.9 g, 5.02 mmol), 6-chloro-l-methyl-lH-imidazo[4,5- c]pyridine (0.802 g, 4.788 mmol) and sodium tert-butoxide (0.689 g, 7.18 mmol) were suspended in 1,4- dioxane (40 mL). The reaction was stirred under an atmosphere of N2 (g) for 20 min then tris(dibenzylideneacetone)dipalladium(0) (219 mg, 0.23 mmol) and 2-dicyclohexylphosphino-2',4',6'- triisopropylbiphenyl (228 mg, 0.478 mmol) were added. The reaction was heated to 85C for 4 h then concentrated in vacuo. The crude material was dissolved in MeOH (40 mL) and HC1 (4 mL, 4 M in dioxane) and the reaction was refluxed for 4 h to re-esterify the hydrolysed ester. The reaction was concentrated in vacuo, diluted with EtOAc and washed with water then brine. The organic layer was dried (MgSO i), filtered and concentrated in vacuo. The residue was purified by column chromatography using silica gel and eluting with DCM:MeOH 97:3 to give the desired compound
 

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