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Chemical Structure| 15258-73-8 Chemical Structure| 15258-73-8
Chemical Structure| 15258-73-8

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Product Details of 2,6-Dichlorobenzyl alcohol

CAS No. :15258-73-8
Formula : C7H6Cl2O
M.W : 177.03
SMILES Code : OCC1=C(Cl)C=CC=C1Cl
MDL No. :MFCD00004609
InChI Key :WKKHCCZLKYKUDN-UHFFFAOYSA-N
Pubchem ID :27156

Safety of 2,6-Dichlorobenzyl alcohol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 2,6-Dichlorobenzyl alcohol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15258-73-8 ]

[ 15258-73-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1025707-93-0 ]
  • [ 15258-73-8 ]
  • [ 1401300-24-0 ]
  • 2
  • [ 124467-36-3 ]
  • [ 15258-73-8 ]
  • 2-((2,6-dichlorobenzyl)oxy)-7,8-dihydroquinolin-5(6H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% A solution of(2,6-dichlorophenyl)methanol (1.07 g, 6.06 mmol) in DMF (15 mL) was treated with NaH (60% in mineral oil; 661 mg, 16.5 mmol) and stirred at rt for 15 mm. The mixture was treated with 2-chloro-7,8-dihydroquinolin-5(6B)-one (1.00 g, 5.51mmol) and stirred at rt for 1.5 h. Chipped ice (5 g) was added and the mixture was extracted twice with EtOAc. The combine organic phases were washed with brine, dried and concentrated. The residue was subjected to column chromatography on silica gel, eluting with EtOAc-hexanes (0-40%), to provide 2-((2,6-dichlorobenzyl)oxy)-7,8- dihydroquinolin-5(6B)-one (1.35 g, 76% yield). LCMS m/z 321.8, 323.8, 325.8 (M+H), HPLC tR 3.71 mm (method B). 1H NMR (400 MHz, CDCl3) delta 8.21 (d, J=8.58 Hz, 1H), 7.37-7.44 (m, 2H), 7.20-7.33 (m, 1H), 6.71 (d, J=8.58 Hz, 1H), 5.69 (s, 2H), 3.09 (t, J=6.16 Hz, 2H), 2.62-2.70 (m, 2H), 2.14-2.28 (m, 2H).
 

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