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Chemical Structure| 1520-31-6 Chemical Structure| 1520-31-6

Structure of 1520-31-6

Chemical Structure| 1520-31-6

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Product Details of [ 1520-31-6 ]

CAS No. :1520-31-6
Formula : C2H7NOS
M.W : 93.15
SMILES Code : O=S(C)(C)=N
MDL No. :MFCD02656633
InChI Key :DTGSFFWQUULHIF-UHFFFAOYSA-N
Pubchem ID :123119

Safety of [ 1520-31-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P261-P271

Application In Synthesis of [ 1520-31-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1520-31-6 ]

[ 1520-31-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1520-31-6 ]
  • [ 543740-89-2 ]
  • 6-amino-N-[dimethyl(oxido)-λ4-sulfanylidene]-5-iodonicotinamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diisopropylamine; In N,N-dimethyl-formamide; at 70℃; for 1.5h;Inert atmosphere; To a 250 mL round bottom flask containing 5-iodo-6-amino-nicotinic acid (5 g, 18.9 mmol) and dimethylsulfoximine (1.94 g, 1.1 eq) in anhydrous DMF (50 mL) was added diisopropylamine (6.6 mL, 2 eq) and BOP (9.21 g, 1.1 eq) under nitrogen atmosphere. The reaction mixture was heated at 70 C. for 1.5 hours and then partitioned between aq NH4Cl and EtOAc. The aqueous layer was separated and extracted once with EtOAc. The two organic layers were combined, and washed with saturated aq NaHCO3/brine (1:1, 1×), brine (1×), and dried with anhydrous Na2SO4. The solution layer was decanted, concentrated, and the brown solid residue was treated with EtOAc with stirring at RT for 30 minutes. The solid which formed was colleded by filtration and dried to give the title compound as an offwhite solid (5.31 g, 83%).
 

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