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Chemical Structure| 150542-06-6 Chemical Structure| 150542-06-6

Structure of 150542-06-6

Chemical Structure| 150542-06-6

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Product Details of [ 150542-06-6 ]

CAS No. :150542-06-6
Formula : C8H5F2IO
M.W : 282.03
SMILES Code : IC(F)(F)C(C1=CC=CC=C1)=O
MDL No. :MFCD34648081

Safety of [ 150542-06-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335-H227
Precautionary Statements:P210-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of [ 150542-06-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 150542-06-6 ]

[ 150542-06-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 149-30-4 ]
  • [ 150542-06-6 ]
  • [ 943-08-8 ]
YieldReaction ConditionsOperation in experiment
92% With water; sodium hydroxide; In acetonitrile; at 20℃; for 0.166667h; General procedure: A mixture of 8 or 10 (1 mmol), NaOH (11 mmol, 0.44 g) was dissolved in CH3CN (CH3CN/H2O 10/1, V/V, 11 mL) in an oven dried 50 mL round bottom flask containing a stir bar. Iododifluoroacetophenone (2) (2 mmol, 0.56 g), was added to the reaction mixture and stirred at room temperature for about 10 min. After the reaction was completed as indicated by TLC the reaction mixture was removed under reduced pressure. And then, the reaction mixture was diluted with water (50 mL) and extracted with EtOAc (25 mL x 3), followed by brine (50 mL). The organic extract was dried over NaSO4, filtered and evaporated under reduced pressure. The crude product was further purified by silica gel column chromatography using (pet ether/EtOAc) to furnish the S- and O-CF2H derivatives 9a-9h and 11a-11h.
  • 2
  • [ 2268-77-1 ]
  • [ 150542-06-6 ]
  • 2-((difluoromethyl)thio)-4-methylbenzo[d]thiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With water; sodium hydroxide; In acetonitrile; at 20℃; for 0.166667h; General procedure: A mixture of 8 or 10 (1 mmol), NaOH (11 mmol, 0.44 g) was dissolved in CH3CN (CH3CN/H2O 10/1, V/V, 11 mL) in an oven dried 50 mL round bottom flask containing a stir bar. Iododifluoroacetophenone (2) (2 mmol, 0.56 g), was added to the reaction mixture and stirred at room temperature for about 10 min. After the reaction was completed as indicated by TLC the reaction mixture was removed under reduced pressure. And then, the reaction mixture was diluted with water (50 mL) and extracted with EtOAc (25 mL x 3), followed by brine (50 mL). The organic extract was dried over NaSO4, filtered and evaporated under reduced pressure. The crude product was further purified by silica gel column chromatography using (pet ether/EtOAc) to furnish the S- and O-CF2H derivatives 9a-9h and 11a-11h.
 

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