Home Cart Sign in  
Chemical Structure| 1501-06-0 Chemical Structure| 1501-06-0

Structure of 1501-06-0

Chemical Structure| 1501-06-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1501-06-0 ]

CAS No. :1501-06-0
Formula : C11H18O5
M.W : 230.26
SMILES Code : O=C(OCC)C(C(C)=O)CCC(OCC)=O
MDL No. :MFCD00009158

Safety of [ 1501-06-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1501-06-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1501-06-0 ]

[ 1501-06-0 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 1501-06-0 ]
  • [ 6414-69-3 ]
  • [ 72948-75-5 ]
  • 3
  • [ 1501-06-0 ]
  • [ 1903-91-9 ]
  • [ 159237-69-1 ]
YieldReaction ConditionsOperation in experiment
4.6 g (42%) With NaOEt; In ethanol; water; Step 1 Ethyl 3-(6-Methyl-2-methoxymethyl-3H-pyrimidin-4-on-5-yl)propionate A mixture of NaOEt (0.088 mol) in EtOH (prepared from 2.0 g of Na and 70 mL of EtOH), <strong>[1903-91-9]methoxyacetamidine hydrochloride</strong> (5.4 g, 0.044 mol), and diethyl acetylglutarate (10.0 g, 0.044 mol) was heated under reflux for 24 h. The mixture was concentrated, taken up in water, acidified to pH 4 with conc. HCl, and extracted with CH2 Cl2. The extracts were washed with brine, dried (MgSO4), and concentrated. Trituration with ether gave 4.6 g (42%) of product as an off-white solid, mp 87-90 C. 1 H NMR (DMSO-d6) delta1.15 (t, J=7.2 Hz, 3H), 2.22 (s, 3H), 2.45 (s, 3H), 2.63 (t, J=7.8 Hz, 2H), 3.30 (s, 3H), 4.08 (q, J=7.2 Hz, 2H), 4.18 (s, 2H), 12.40 (br s, 1H).
  • 4
  • [ 1501-06-0 ]
  • [ 56469-10-4 ]
  • ethyl 7-(1',1'-dimethylheptyl)-5-hydroxy-4-methyl-2-oxy-2H-1-benzopyran-3-propionate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With trichlorophosphate; In ethyl acetate; PREPARATION 1 Preparation of 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. A mixture containing 114 g. of <strong>[56469-10-4]5-(1',1'-dimethylheptyl) resorcinol</strong>, 112 g. of diethyl 2-acetylglutarate and 74 g. of phosphorous oxychloride was stirred at ambient temperature for about ten days. The reaction mixture was then dissolved in ethyl acetate and the ethyl acetate layer washed several times with an equal volume of water until the water wash was neutral to litmus. The organic layer was separated and dried, and the solvent removed by evaporation in vacuo. The residue, comprising ethyl 7-(1',1'-dimethylheptyl)-5-hydroxy-4-methyl-2-oxy-2H-1-benzopyran-3-propionate formed in the above reaction, was purified by chromatography over 2 kg. of neutral alumina using chloroform as the eluant.
With trichlorophosphate; In ethyl acetate; EXAMPLE 1 Preparation of 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one A mixture containing 114 g. of <strong>[56469-10-4]5-(1',1'-dimethylheptyl)resorcinol</strong>, 112 g. of diethyl 2-acetylglutarate and 74 g. of phosphorous oxychloride was stirred at ambient temperature for about 10 days. The reaction mixture was then dissolved in ethyl acetate and the ethyl acetate layer washed several times with an equal volume of water until the water wash was neutral to litmus. The organic layer was separated and dried, and the solvent removed by evaporation in vacuo. The residue, comprising ethyl 7-(1',1'-dimethylheptyl)-5-hydroxy-4-methyl-2-oxy-2H-1-benzopyran-3-propionate formed in the above reaction, was purified by chromatography over 2 kg. of neutral alumina using chloroform as the eluant.
With trichlorophosphate; In ethyl acetate; EXAMPLE 1 Preparation of 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one A mixture containing 114 g. of <strong>[56469-10-4]5-(1',1'-dimethylheptyl)resorcinol</strong>, 112 g. of diethyl 2-acetylglutarate and 74 g. of phosphorous oxychloride was stirred at ambient temperature for about ten days. The reaction mixture was then dissolved in ethyl acetate and the ethyl acetate layer washed several times with an equal volume of water until the water wash was neutral to litmus. The organic layer was separated and dried, and the solvent removed by evaporation in vacuo. The residue, comprising ethyl 7-(1',1'-dimethylheptyl)-5-hydroxy-4-methyl-2-oxy-2H-1-benzopyran-3-propionate formed in the above reaction, was purified by chromatography over 2 kg. of neutral alumina using chloroform as the eluant.
  • 5
  • [ 1501-06-0 ]
  • [ 6100-60-3 ]
  • C16H18O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With methanesulfonic acid; at 20℃; for 12h; To a suspension of compound 1 (8.8 g, 0.063 mol) in compound 2 (18 g, 0.078 mol), CH3SO3H (144 mL) was added in one portion. The mixture was stirred at RT for 12 h. LC-MS showed that starting material was consumed completely. The reaction mixture was poured into ice-water (300 mL) and stirred for 30 min. The formed precipitate was filtered and washed with water and EA, dried to afford the crude Compound 3 (11.2 g, 59%) as white solid;
 

Historical Records

Technical Information

Categories