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Chemical Structure| 149602-64-2 Chemical Structure| 149602-64-2

Structure of 149602-64-2

Chemical Structure| 149602-64-2

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Product Details of [ 149602-64-2 ]

CAS No. :149602-64-2
Formula : C8H16N4O2
M.W : 200.24
SMILES Code : O=C(OC(C)(C)C)NC(C)CN=[N+]=[N-]
MDL No. :MFCD22369926

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Application In Synthesis of [ 149602-64-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 149602-64-2 ]

[ 149602-64-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 149602-64-2 ]
  • [ 255735-88-7 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium 10% on activated carbon; In methanol; at 20℃; for 14h; After 10percent palladium carbon (100 mg) was added to a methanol (30 ml) solution of the compound (1.00 g) obtained in Referential Example 339, the resulting mixture was stirred at room temperature for 14 hours under a hydrogen atmosphere. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was dissolved in N,N-dimethylformamide (20 ml). The compound (1.12 g) obtained in Referential Example 9, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.15 g) and 1-hydroxybenzotriazole (0.676 g) were added. After stirring overnight at room temperature, stirring was conducted further at 40°C for 4 days. The reaction mixture was concentrated under reduced pressure. Chloroform was added to the residue. The resulting mixture was washed successively with a saturated aqueous solution of sodium bicarbonate and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue purified by chromatography (methylene chloride:methanol = 98:2 --> 95:5) on a silica gel column, whereby the title compound (1.01 g) was obtained.1H-NMR(CDCl3) delta: 1.20(3H,d,J=6.6Hz), 1.44(9H,s), 3.29-3.41(1H,m), 3.42-3.51(1H,m), 3.91(1H,br s), 4.55(1H,br s), 7.71(1H,dd,J=9.0,2.4Hz), 7.99(1H,br s), 8.20(1H,d,J=9.0Hz), 8.31(1H,d,J=2.4Hz), 9.73(1H,s). MS(ESI)m/z: 357(M+H)+.
 

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