Home Cart Sign in  
Chemical Structure| 149104-88-1 Chemical Structure| 149104-88-1
Chemical Structure| 149104-88-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Paul Getreuer ; Laura Marretta ; Emine Toyoglu ; Orsolya Dömötör ; Michaela Hejl ; Alexander Prado-Roller , et al.

Abstract: In this contribution we report the synthesis, characterization and in vitro anticancer activity of novel cyclometalated 4-phenylthiazole-derived ruthenium(II) (2a–e) and osmium(II) (3a–e) complexes. Formation and sufficient purity of the complexes were unambigiously confirmed by 1H-, 13C- and 2D-NMR techniques, X-ray diffractometry, HRMS and elemental analysis. The binding preferences of these cyclometalates to selected amino acids and to DNA models including G-quadruplex structures were analyzed. Additionally, their stability and behaviour in aqueous solutions was determined by UV-Vis spectroscopy. Their cellular accumulation, their ability of inducing apoptosis, as well as their interference in the cell cycle were studied in SW480 colon cancer cells. The anticancer potencies were investigated in three human cancer cell lines and revealed IC50 values in the low micromolar range, in contrast to the biologically inactive ligands.

Purchased from AmBeed: ; ; ; ; ; ;

Alternative Products

Product Details of 4-(Methylsulfonyl)phenylboronic acid

CAS No. :149104-88-1
Formula : C7H9BO4S
M.W : 200.02
SMILES Code : C1=C([S](=O)(=O)C)C=CC(=C1)B(O)O
MDL No. :MFCD01630820
InChI Key :VDUKDQTYMWUSAC-UHFFFAOYSA-N
Pubchem ID :2734364

Safety of 4-(Methylsulfonyl)phenylboronic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 4-(Methylsulfonyl)phenylboronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 149104-88-1 ]

[ 149104-88-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1010120-55-4 ]
  • [ 149104-88-1 ]
  • [ 1257704-24-7 ]
YieldReaction ConditionsOperation in experiment
33% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; N,N-dimethyl-formamide; at 80℃; for 18h;Inert atmosphere; Sealed tube; A dry tube was charged with tetrakis(triphenylphopshine)palladium(0) (1.29 g, 1.1 mmol), 5-bromo-[l,2,4]triazolo[l,5-a]pyridin-2-ylamine (2.98 g, 14.0 mmol), (4- methylsulfonylphenyl) boronic acid (3.08 g, 15.4 mmol), sodium carbonate (3.26 g, 31.04 mmol), dioxane (30 mL), N,N-dimethylformamide (60 mL) and water (30 mL). The tube was evacuated with a high vacuum and backflushed under a stream of nitrogen three times. The mixture was stirred for 2 minutes at room temperature under nitrogen then the tube was sealed and heated at 800C for 18 hours. The mixture was transferred to a round bottom flask and evaporated under reduced pressure. Water (100 mL) was added and solution extracted with dichloromethane (3 portions of 50 mL). The combined organic was dried over magnesium sulfate, filtered and evaporated. The solid was triturated with ether/dichloromethane (4:1; 10 mL), filtered and rinsed with ether. The recovered material was consistent for 5-(4-methanesulfonyl-phenyl)-[l,2,4]triazolo[l,5-a]pyridin-2-ylamine (1.3 g, 33%). 1H NMR (400 MHz, CDCl3, delta, ppm): 8.21 (d, J = 8.0 Hz, 2H) 8.08 (d, J = 8.0 Hz, 2H), 7.55 (m, IH), 7.44 (d, J = 9.1 Hz, IH), 7.13 (d, J = 7.5 Hz, IH), 6.10 (br s, 2H) 3.31 (s, 3H). MS = 289 (MH)+.
  • 2
  • [ 138006-41-4 ]
  • [ 149104-88-1 ]
  • [ 202409-86-7 ]
 

Historical Records

Technical Information

Categories