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Chemical Structure| 148672-79-1 Chemical Structure| 148672-79-1

Structure of 148672-79-1

Chemical Structure| 148672-79-1

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Product Details of [ 148672-79-1 ]

CAS No. :148672-79-1
Formula : C9H18N2
M.W : 154.25
SMILES Code : NCC12CCCN(C2)CCC1
MDL No. :MFCD20723445

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Application In Synthesis of [ 148672-79-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 148672-79-1 ]

[ 148672-79-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 148672-79-1 ]
  • [ 7151-76-0 ]
  • [ 530-62-1 ]
  • N-(1-Azabicyclo[3.3.1non-5-ylmethyl)-4-[(methylsulfonyl)aminol]benzamide [ No CAS ]
  • sesquihydrate [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.61 g (32%) In tetrahydrofuran; N-methyl-acetamide; methanol; acetonitrile; EXAMPLE 9 N-(1-Azabicyclo[3.3.1non-5-ylmethyl)-4-[(methylsulfonyl)aminol]benzamide A solution/suspension of 4-[(methanesulfonyl)amino]benzoic acid (1.08 g, 5.0 mmol) in anhydrous 1:1 tetrahydrofuran/dimethylformamide (4 mL) was treated with 1,1'-carbonyldiimidazole (0.89 g, 5.5 mmol), stirred for one hour, then degassed over 15 minutes under a stream of nitrogen. A solution of 1-azabicyclo[3.3.1]nonane-5-methanamine (0.85 g, 5.5 mmol) in anhydrous tetrahydrofuran (4 mL) was added, and the mixture was stirred at room temperature for 18 hours and at 50 C. for three hours, then concentrated in vacuo. The residue was triturated from acetonitrile/ether, then dissolved in 3.2 tetrahydrofuran/methanol and filtered through a short column of alumina (eluted with 3:2 tetrahydrofuran/methanol). The filtrate was concentrated in vacuo and recrystallized (2 crops) from 2-propanol/ether to afford 0.61 g (32%) of the sesquihydrate of the title compound as a voluminous colorless solid; mp 137-139 C. (foam). Analysis: Calc. for C17 H25 N3 O3 S.1.5H2 O: C, 53.95; H, 7.46; N, 11.10. Found: C, 54.14; H, 7.35; N, 10.49.
 

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