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Chemical Structure| 14804-32-1 Chemical Structure| 14804-32-1

Structure of 14804-32-1

Chemical Structure| 14804-32-1

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Product Details of [ 14804-32-1 ]

CAS No. :14804-32-1
Formula : C9H12O
M.W : 136.19
SMILES Code : COC1=CC=CC=C1CC
MDL No. :MFCD00142909

Safety of [ 14804-32-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H227
Precautionary Statements:P210-P264-P270-P280-P301+P312-P330-P370+P378-P403+P235-P501

Application In Synthesis of [ 14804-32-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 14804-32-1 ]
  • Downstream synthetic route of [ 14804-32-1 ]

[ 14804-32-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 14804-32-1 ]
  • [ 33839-11-1 ]
YieldReaction ConditionsOperation in experiment
98% With N-Bromosuccinimide In acetonitrile at 20℃; for 18 h; 4-Bromo-2-ethyl-l-methoxybenzene 5. To a stirred solution of 2-ethyl anisole (3.2 g5 23.5 mmol) in MeCN (100 mL) was added N-bromo succinimide (4.59 g, 25.8 mmol) and the reaction was stirred at rt for 18 h before being concentrated under reduced pressure. To the crude mix was added diethyl ether (100 mL) and the solution washed with water (2 x 100 mL). The ether layer was concentrated under reduced pressure and the product purified by flash chromatography using hexane to EtOAc as eluent (Rf 0.9, 30percent EtOAc in hexane) to give colourless oil, 4.95 g, 98percent: 1H NMR δ (270 MHz5 CDCl3) 1.16 (t5 J= 7.5 Hz5 3H)5 2.59 (q, J= 7.5 Hz52H), 3.79 (s, 3H)5 6.69 (d, J= 9.4 Hz, IH), 7.23-7.26 (m, 2H).
References: [1] Patent: WO2007/96647, 2007, A2, . Location in patent: Page/Page column 91.
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984, vol. 20, # 8, p. 838 - 841[3] Khimiya Geterotsiklicheskikh Soedinenii, 1984, vol. 20, # 8, p. 1035 - 1038.
 

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