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Chemical Structure| 1476847-52-5 Chemical Structure| 1476847-52-5

Structure of 1476847-52-5

Chemical Structure| 1476847-52-5

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Product Details of [ 1476847-52-5 ]

CAS No. :1476847-52-5
Formula : C18H15BrO4
M.W : 375.21
SMILES Code : BrCC(C1=CC2=C(OCC3=CC=CC=C3)C=C(OC)C=C2O1)=O
MDL No. :MFCD28977511

Safety of [ 1476847-52-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1476847-52-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1476847-52-5 ]

[ 1476847-52-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50840-23-8 ]
  • [ 1476847-52-5 ]
  • 2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimidazo[1,2-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
61.4% In isopropyl alcohol; at 20 - 80℃; for 40h; In an 80 mE high pressure vessel under nitrogen,mixture of <strong>[50840-23-8]5-methylpyrimidin-2-amine</strong> (0.245 g, 2.245 mmol) and 1 -(4-(benzyloxy)-6-methoxybenzothran-2-yl)-2- bromoethanone (0.599 g, 1.596 mmol) in 2-propanol (16 mE) was stirred at room temperature for 16 h and a further 24 h at 80 C. The cooled mixture was diluted with dichloromethane and the organic solution was washed once with saturated aqueous sodium bicarbonate, once with brine and finally it was dried over anhydrous sodium sulfate andconcentrated in vacuo. The residue was purified on the ISCO using a 40 g Innoflash column (Hexane/EtOAc) and the solid obtained was triturated with methanol to give2-(4-(benzyloxy)-6-methoxybenzofuran-2-yl)-6-methylimi- dazo[1,2-a]pyrimidine (0.378 mg, 61.4%) as a beige solid. EC (Analytical Method A): 2.117 mm; (Analytical Method B): 2.3 14 mi HRMS (ESI): calcd for C23H2QN303 [M+H] mlz 386.1499; found 386.1488. ?H NMR (400 MHz,DMSO-d5) oe 8.79 (dd, J=1.2, 2.3 Hz, 1H), 8.46 (d, J=2.3 Hz,1H), 8.19 (s, 1H), 7.56-7.50 (m, 2H), 7.46-7.39 (m, 2H),7.38- 7.32 (m, 1H), 7.24 (d, J=0.8 Hz, 1H), 6.90-6.87 (m,1H), 6.55 (d, J=2.0 Hz, 1H), 5.28 (s, 2H), 3.81 (s, 3H), 2.323H).
 

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