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Chemical Structure| 147676-95-7 Chemical Structure| 147676-95-7

Structure of 147676-95-7

Chemical Structure| 147676-95-7

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Product Details of [ 147676-95-7 ]

CAS No. :147676-95-7
Formula : C11H12O4
M.W : 208.21
SMILES Code : O=C(O)C1=CC(C(C)=O)=CC=C1OCC
MDL No. :MFCD14536341

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Application In Synthesis of [ 147676-95-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 147676-95-7 ]

[ 147676-95-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 79-37-8 ]
  • [ 147676-95-7 ]
  • [ 1885-32-1 ]
  • [ 522629-78-3 ]
YieldReaction ConditionsOperation in experiment
44% In pyridine; N-methyl-acetamide; dichloromethane; Preparation 14 2-(5-Acetyl-2-ethoxybenzamido)-3-methylbenzamide Oxalyl chloride (3.66 g, 0.0288 mol) was added dropwise to a stirred solution of 5-acetyl-2-ethoxy-benzoic acid (3 g, 0.00144 mol) and dimethylformamide (0.1 ml) in dichloromethane (15 ml). The mixture was stirred at room temperature for 3 hours, then the solvent evaporated under vacuum and the residue azeotroped with hexane (3*50 ml). The crude acyl chloride was dissolved in dichloromethane (20 ml) and the solution added dropwise to a stirred solution of <strong>[1885-32-1]2-amino-3-methylbenzamide</strong> (2.16 g, 0.0144 mol) in pyridine (40 ml) at 0 C. The mixture was allowed to warm to room temperature and stirred for a further 18 hours. The solvent was removed by evaporation under vacuum, the residue dissolved in dichloromethane (50 ml) and this solution then washed with saturated aqueous sodium carbonate solution (50 ml), 2N hydrochloric acid (50 ml) and brine (50 ml), then dried (Na2SO4) and evaporated under vacuum. Trituration of the residue with diethyl ether gave the title compound as a white solid (2.14 g, 44%), m.p. 214-216 C.
  • 2
  • [ 79-37-8 ]
  • [ 147676-95-7 ]
  • [ 1885-32-1 ]
  • 2-(5-Acetyl-ethoxybenzamido)-3-methylbenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
44% In pyridine; N-methyl-acetamide; dichloromethane; PREPARATION 14 2-(5-Acetyl-ethoxybenzamido)-3-methylbenzamide Oxalyl chloride (3.66 g, 0.0288 mol) was added dropwise to a stirred solution of 5-acetyl-2-ethoxybenzoic acid (3 g, 0.00144 mol) and dimethylformamide (0.1 ml) in dichloromethane (15 ml). The mixture was stirred at room temperature for 3 hours, then the solvent evaporated under vacuum and the residue azeotroped with hexane (3*50 ml). The crude acyl chloride was dissolved in dichloromethane (20 ml) and the solution added dropwise to a stirred solution of <strong>[1885-32-1]2-amino-3-methylbenzamide</strong> (2.16 g, 0.0144 mol) in pyridine (40 ml) at 0 C. The mixture was allowed to warm to room temperature and stirred for a further 18 hours. The solvent was removed by evaporation under vacuum, the residue dissolved in dichloromethane (50 ml) and this solution then washed with saturated aqueous sodium carbonate solution (50 ml), 2N hydrochloric acid (50 ml) and brine (50 ml), then dried (Na2 SO4) and evaporated under vacuum. Trituration of the residue with diethyl ether gave the title compound as a white solid (2.14 g, 44%), m.p. 214-216 C. Found: C,66.81; H,5.98; N,8.16. C19 H20 N2 O4 requires C,67.04; H,5.92; N,8.23%.
 

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