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Chemical Structure| 14763-20-3 Chemical Structure| 14763-20-3

Structure of 14763-20-3

Chemical Structure| 14763-20-3

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Product Details of [ 14763-20-3 ]

CAS No. :14763-20-3
Formula : C6H7ClN2
M.W : 142.59
SMILES Code : NNC1=CC=CC(Cl)=C1
MDL No. :MFCD02656655

Safety of [ 14763-20-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H318-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P310+P330-P302+P352-P304+P340+P312-P305+P351+P338+P310-P332+P313-P403+P233-P405-P501
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 14763-20-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14763-20-3 ]

[ 14763-20-3 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 2689-69-2 ]
  • [ 14763-20-3 ]
  • 3-[(3-chloro-phenyl)-hydrazono]-tetrahydro-thiophene-2-carboxylic acid methyl ester [ No CAS ]
  • 2
  • [ 391-12-8 ]
  • [ 14763-20-3 ]
  • 3-[(3-chloro-phenyl)-hydrazono]-7-trifluoromethyl-1,3-dihydro-indol-2-one [ No CAS ]
  • 3
  • [ 21279-62-9 ]
  • [ 14763-20-3 ]
  • 3-(2-(3-chlorophenyl)hydrazinyl)pyrazine-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
24% With pyridine; In methanol; at 140℃; under 112.51100000000001 Torr; for 0.5h;Microwave irradiation; Compound 8 is prepared by reaction of 3-chlorophenylhydrazine (3 mmol) with 3- chloropyrazine-2-carboxamide (ifi, 1 mmol) in 3 mL methanol and pyridine (1 mniol). The reaction is performed in a microwave reactor at the temperature 140C, pressure 15 kPa and an output of 120 W during 30 mm. After completing the reaction, product 8 was isolated and purified by column chromatography on silica gel (mobile phase: hexane I ethyl acetate 1:1), yield 24%. Analytical data for compound 8: Dark brown crystalline solid; Mp. = 119.5- 120.9C; Elemental analysis calculated for C11H10C1N50 (m.w. 263.68): 50.10% C, 3.82% H, 26.56% N; found 50.3 1% C, 3.7 1% H, 26,55% N; IR (ATR-Ge, cm?): 3445 (-NH-), 3253 (-CONH2), 1671 (-C=O), 1598, 1522, 1476, 1413 (pyr); 1H-NMR (300 MHz, CDC13) ?HNMR (300 MHz, CDCI3) 8.34 (2H, bs, NH2), 7.92 (2H, bs, H5, H6), 7.63 - 6.82 (4H, m,1-12?, H4?, H5?, 116?), 5.71 (211, bs, NH); ?3C NMR (75 MHz, DMSO) & 168,89, 152.20,146.20, 140.24, 134.40, 132.36, 129.72, 126.57, 122.94, 120.26, 118.52; Lipophilicity: caic.values log P 0.34; experimental determined values log k = 0.5898.
  • 4
  • [ 3314-30-5 ]
  • [ 14763-20-3 ]
  • (E)-2-((2-(3-chlorophenyl)hydrazono)methyl)-1H-benzo[d]imidazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
66.7% In methanol; at 20℃; for 2h; General procedure: The equimolar aldehyde 3a?3d (1 mmol) and substituted phenylhydrazine 5a?5s (1 mmol) weremixed in CH3OH (10 mL) and stirred at room temperature [18]. After about 2 h, the reaction wascompleted (monitored by TLC). The residual crude was purified via silica gel column chromatogramusing a gradient mixture of petroleum ether and ethyl acetate to obtain the pure target compounds6a?6ai (in 45?80percent yield).
 

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