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Chemical Structure| 1470-57-1 Chemical Structure| 1470-57-1

Structure of 1470-57-1

Chemical Structure| 1470-57-1

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Product Details of [ 1470-57-1 ]

CAS No. :1470-57-1
Formula : C14H12O2
M.W : 212.24
SMILES Code : O=C(C1=CC=CC=C1)C2=CC(C)=CC=C2O
MDL No. :MFCD00002379

Safety of [ 1470-57-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1470-57-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1470-57-1 ]

[ 1470-57-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1470-57-1 ]
  • [ 13790-39-1 ]
  • {2-[(6,7-dimethoxy-4-quinazolyl)oxy]-5-methylphenyl}-(phenyl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% Compound 161: {2-[(6,7-Dimethoxy-4-quinazolyl)oxy]-5-methylphenyl}-(phenyl)methanone; 4-Chloro-6,7-dimethoxyquinazoline (59 mg), 2-hydroxy-5-methylbenzophenone (279 mg), and 4-dimethylaminopyridine (168 mg) were suspended in o-dichlorobenzene (5 ml), and the suspension was stirred at 160C for 10 min. The reaction solution was cooled to room temperature, the solvent was then removed therefrom by distillation under the reduced pressure, and chloroform was added to the residue. The mixture was washed with a 1 N aqueous potassium hydroxide solution and saturated brine and was dried over anhydrous magnesium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography using chloroform and by thin layer chromatography using acetone-hexane to give the title compound (97 mg, yield 92%). 1H-NMR (CDCl3, 400 MHz): δ 2.46 (s, 3H), 3.90 (s, 3H), 4.01 (s, 3H), 7.03 (s, 1H), 7.19 (s, 1H), 7.22 - 7.27 (m, 2H), 7.31 (d, J = 8.6 Hz, 1H), 7.33 - 7.39 (m, 1H), 7.43 - 7.49 (m, 2H), 7.67 - 7.73 (m, 2H), 8.49 (s, 1H) Mass spectrometric value (ESI-MS, m/z): 401 (M+1)+
 

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