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Chemical Structure| 146949-07-7 Chemical Structure| 146949-07-7

Structure of 146949-07-7

Chemical Structure| 146949-07-7

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Product Details of [ 146949-07-7 ]

CAS No. :146949-07-7
Formula : C9H11ClO2S
M.W : 218.70
SMILES Code : O=S(C1=CC=C(CCC)C=C1)(Cl)=O
MDL No. :MFCD00041508
InChI Key :LEFGAGRZHLNPLS-UHFFFAOYSA-N
Pubchem ID :2737222

Safety of [ 146949-07-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 146949-07-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 146949-07-7 ]

[ 146949-07-7 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 53838-27-0 ]
  • [ 146949-07-7 ]
  • (S)-2-(4-Propyl-benzenesulfonylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester [ No CAS ]
  • 2
  • [ 21344-90-1 ]
  • [ 146949-07-7 ]
  • [ 376349-32-5 ]
YieldReaction ConditionsOperation in experiment
276A N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-propylbenzenesulfonamide The title compound was prepared from <strong>[21344-90-1]4-(2-chlorophenyl)-1,3-thiazol-2-amine</strong> and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (30.9 mg) with purity >90percent. MS (pos) m/z 393.1.
  • 3
  • [ 580-15-4 ]
  • [ 146949-07-7 ]
  • 4-propyl-N-quinolin-6-yl-benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% Synthesis of 4-propyl-N-quinolin-6-vl-benzenesulfonamide, STX 933 (KRB01059) :; To a solution of 4n-propylbenzenesulphonyl chloride (159 mg, 0.728 mmol) in dichloromethane (4 mL) was added pyridine (140 uL, 1.74 mmol) and the mixture was stirred under N2 for 5 min, after which time <strong>[580-15-4]6-aminoquinoline</strong> (100 mg, 0.694 mmol) was added. The resulting mixture was stirred for 2 h at room temperature, then saturated NaHCO3 solution (10 mL) was added and the mixture was extracted into ethyl acetate (20 mL). The organic phase was washed with brine, dried (Na2SO4), filtered and evaporated to give a residue that was purified using flash chromatography to afford a white solid (210 mg, 93%), single spot at Rf 0.71 (ethyl acetate). mp 180.1-180. 7C, HPLC purity 99+% (tR 2.37 min in 10% water-acetonitrile).'H NMR (CDC13) : 5 8.83 (1H, dd, J=4.2, 1.7 Hz), 8.05 (1H, d, J=8.4 Hz), 7.97 (1H, d, J=9.2 Hz), 7.70 (2H, d, J=8.2 Hz), 7.57 (1H, d, J=2.5 Hz), 7.40-7. 34 (2H, m), 7.22 (2H, m), 6.85 (1H, s, N-H), 2.57 (2H, t, J=7.2 Hz), 1.57 (2H, sextet, J=7.2 Hz), 0.87 (3H, t, J=7.3 Hz). LCMS: 325.23 (M- ). FAB-MS (MH+, C18H18N2O2S) : calcd 327.1167, found 327.1167.
  • 4
  • [ 6174-86-3 ]
  • [ 146949-07-7 ]
  • 3-chloro-4-methyl-2-oxo-2H-chromen-7-yl 4-propylbenzenesulfonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With triethylamine; In tetrahydrofuran; at 20℃; for 4h; General procedure: Coumarin sulfonates 1-38 were synthesized by reactingdifferent hydroxylated coumarin derivatives (1 mmol) withcommercially available sulfonyl chlorides derivatives (1.2 mmol) inTHF (15 mL) and triethyl amine (1 mmol) was used as base. Reactionmixture was stirred for 4 h at room temperature to afford avariety of coumarin sulfonate esters 1e38. TLC monitoring wasused to determine the progress of the reaction. After the completionof reaction, THF was evaporated under reduced pressure andthe solid product obtained was washed with distilled water anddried under vacuum. The products were recrystallized in methanoland gave good yields. All the synthetic compounds 1-38 werecharacterized by different spectroscopic techniques such as EI-MS,HREI-MS, 1H-NMR, and 13C-NMR.
 

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