Home Cart Sign in  
Chemical Structure| 146013-28-7 Chemical Structure| 146013-28-7

Structure of 146013-28-7

Chemical Structure| 146013-28-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 146013-28-7 ]

CAS No. :146013-28-7
Formula : C12H21NO2S2
M.W : 275.43
SMILES Code : CC(C)CC1=CC=C(S1)S(=O)(=O)NC(C)(C)C
MDL No. :MFCD11982554

Safety of [ 146013-28-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P264-P280-P305+P351+P338-P337+P313

Application In Synthesis of [ 146013-28-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 146013-28-7 ]

[ 146013-28-7 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 146013-28-7 ]
  • [ 163520-14-7 ]
YieldReaction ConditionsOperation in experiment
5-ISO-BUTYL-N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10.6 g, 0.039 mol; see step (b) above) was dissolved in THF (165 mL) under N2 AND then cooled to -78C. n-BuLi (1.6 M, 60.19 mL, 0.096 mol) was added via a syringe. The reaction mixture was stirred AT-20C for 4 h. Tri-iso-propylborate (13.3 ML, 0.058 mol) was then added via a syringe and the reaction mixture was stirred overnight at room temperature. The reaction was quenched with 2 M HCl (20 mL). The organic phase was separated and the water phase was extracted with EtOAc (3 x 100 mL). The combined organic phase was washed with brine, dried and concentrated in vacuo. The product may be used without further purification. MS (ESI+) m/z : 236.8
5-ISO-BUTYL-N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10.6 g, 0.039 mol; see step (b) above) was dissolved in THF (165 mL) under N2 and then cooled to -78C. n-BuLi (1.6 M, 60.19 mL, 0.096 mol) was added via a syringe. The reaction mixture was stirred at-20C for 4 h. Tri-iso-propylborate (13.3 mL, 0.058 mol) was then added via a syringe and the reaction mixture was stirred overnight at room temperature. The reaction was quenched with 2 M HCl (20 mL). The organic phase was separated and the water phase was extracted with EtOAc (3 x 100 mL). The combined organic phase was washed with brine, dried and concentrated in vacuo. The product may be used without further purification. MS (ESI+) m/z: 236.8
5-ISO-BUTYL-N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10.6 g, 0.039 mol, see step (b) above) was dissolved IN THF (165 ML) under N2 and then cooled to -78oC. N-BULI (1.6 M, 60.19 ML, 0.096 mol) was added via a syringe. The reaction mixture was stirred at-20oC for 4 H. THE TRI-ISO-PROPYLBORATE (13.3 ML, 0.058 mol) was then added via a syringe and the reaction mixture was stirred overnight at room temperature. The reaction was quenched with 2 M HCl (20 mL). The organic phase was separated and the water phase was extracted with EtOAc (3 x 100 mL). The combined organic phase was washed with brine, dried and concentrated in vacuo. The product may be used without further purification. MS (ESI+) m/z: 236. 8
  • 2
  • [ 513-38-2 ]
  • [ 100342-30-1 ]
  • [ 146013-28-7 ]
YieldReaction ConditionsOperation in experiment
55% N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10 g, 0.046 mol; see step (a) above) was dissolved in THF (85 mL) under N2 and then cooled TO-78C. n-BuLi (1.6 M, 76.9 mL, 0.12 mol) was added via a syringe. The reaction mixture was stirred at-78C for 30 min. and then at-40C for 2 h. IODO-2- methylpropane (10.5 mL, 0.09 mol) was added dropwise to the reaction mixture. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with NH4C1 (aq. ) and extracted with EtOAc. The combined organic phase was washed with brine and dried and concentrated in vacuo. The crude product was purified on column chromatography (hexanes: EtOAc (10: 1) ) to give the sub-title compound in 55% yield (7.0 g, 0.025 mol). 1H NMR 8 (CDC13) : 7.43 (1H, d, J= 3.6 Hz), 6.67 (1H, d, J= 3.8 Hz), 4.83 (1H, M), 2.67 (2H, d, J= 7 Hz), 1.88 (1H, M), 1.26 (9H, M), 0.93 (6H, J= 6.6 Hz). 13C NMR No.(CDCL3) : 145.0, 131.7, 131.2, 127.0, 55.1, 29.9
55% N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10 g, 0.046 mol; see step (a) above) was dissolved in THF (85 mL) under N2 and then cooled TO-78C. n-BuLi (1.6 M, 76.9 mL, 0.12 mol) was added via a syringe. The reaction mixture was stirred AT-78C for 30 min. and then AT-40C for 2 hours. IODO-2- METHYLPROPANE (10.5 mL, 0.09 mol) was added dropwise to the reaction mixture. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with NILCL (aq. ) and extracted with EtOAc. The combined organic phase was washed with brine and dried and concentrated in vacuo. The crude product was purified on column chromatography (hexanes: EtOAc (10: 1) ) to give the sub-title compound in 55% yield (7.0 g, 0.025 mol). 'H NMR 8 (CDC13) : 7.43 (1H, d, J= 3.6 Hz), 6.67 (1H, d, J= 3.8 Hz), 4.83 (1H, m), 2.67 (2H, d, J = 7 Hz), 1. 88 (1H, m), 1.26 (9H, m), 0.93 (6H, J= 6.6 Hz). 13C NMR 8 (CDC13) : 145.0, 131.7, 131.2, 127.0, 55.1, 29.9
55% N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10 g, 0.046 mol, see step (a) above) was dissolved in THF (85 ML) under N2 and then cooled TO-78oC. n-BuLi (1.6 M, 76.9 ML, 0.12 mol) was added via a syringe. The reaction mixture was stirred at-78oC for 30 min. and then AT-40oC for 2 h. IODO-2- methylpropane (10.5 mL, 0.09 mol) was added dropwise to the reaction mixture. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with NH4C1 (aq. ) and extracted with EtOAc. The combined organic phase was washed with brine and dried and concentrated in vacuo. The crude product was purified on column chromatography (hexanes: EtOAc (10: 1) ) to give the sub-title compound in 55% yield (7.0 g, 0.025 mol). H NMR (CDCl3) 8 7.43 (1H, d, J= 3.6 Hz), 6.67 (1H, d, J=3. 8 Hz), 4. 83 (1H, M), 2.67 (2H, d, J=7 Hz), 1. 88 (1H, M), 1.26 (9H, M), 0.93 (6H, J=6.6 HZ). 13C NMR (CDCl3) 6 145. 0, 131. 79 131. 2, 127.0, 55. 1,29. 9
  • 3
  • [ 146013-28-7 ]
  • [ 5419-55-6 ]
  • [ 163520-14-7 ]
YieldReaction ConditionsOperation in experiment
5-ISO-BUTYL-N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10.6 g, 0.039 mol; see step (b) above) was dissolved in THF (165 ML) under N2 and then cooled to -78C. N-BULI (1.6 M, 60.19 mL, 0.096 mol) was added via a syringe. The reaction mixture was stirred at-20C for 4 hours. Tri-iso-propylborate (13.3 mL, 0.058 mol) was then added via a syringe and the reaction mixture was stirred overnight at room temperature. The reaction was quenched with 2 M HCl (20 mL). The organic phase was separated and the water phase was extracted with EtOAc (3 x 100 mL). The combined organic phase was washed with brine, dried and concentrated in vacuo. The product may be used without further purification. MS (ESI+) m/z: 236.8-
  • 4
  • [ 89124-64-1 ]
  • [ 100342-30-1 ]
  • [ 146013-28-7 ]
YieldReaction ConditionsOperation in experiment
55% N-TERT-BUTYLTHIOPHENE-2-SULFONAMIDE (10 g, 0.046 mol; see step (a) above) was dissolved in THF (85 mL) under N2 AND then cooled TO-78C. n-BuLi (1.6 M, 76.9 mL, 0.12 mol) was added via a syringe. The reaction mixture was stirred at-78C for 30 min. and then AT-40C for 2 h. IODO-2- methylpropane (10.5 mL, 0.09 mol) was added dropwise to the reaction mixture. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with NH4CL (aq. ) and extracted with EtOAc. The combined organic phase was washed with brine and dried and concentrated in vacuo. The crude product was purified on column chromatography (hexanes: EtOAc (10: 1) ) to give the sub-title compound in 55% yield (7.0 g, 0.025 mol). 'H NMR 5 (CDC13) : 7.43 (1H, d, J= 3.6 Hz), 6.67 (1H, d, J= 3.8 Hz), 4.83 (1H, m), 2.67 (2H, d, J= 7 Hz), 1.88 (1H, m), 1.26 (9H, m), 0.93 (6H, J= 6.6 Hz). 13C NMR 5 (CDC13) : 145.0, 131.7, 131.2, 127. 0, 55.1, 29.9
  • 5
  • [ 78-77-3 ]
  • [ 100342-30-1 ]
  • [ 146013-28-7 ]
 

Historical Records