1454908-27-0|tert-Butyl ((6-chloropyridazin-3-yl)methyl)carbamate| Ambeed

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1454908-27-0 ]

[ 1454908-27-0 ] Synthesis Path-Downstream 1~1

1
[ 871826-15-2 ]
[ 24424-99-5 ]
[ 1454908-27-0 ]

Yield	Reaction Conditions	Operation in experiment
460 mg	With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20.0℃; for 2.0h;	To a solution of <strong>[871826-15-2](6-chloropyridazin-3-yl)methanamine</strong> (300 mg, 2.0 mmol) in a mixture of THF (9 mL) and water (9 mL), was added NaHCO3 (200 mg, 2.4 mmol) and (Boc)2O (570 mg, 2.6 mmol). The mixture was stirred at 20 C for 2 h, and then the reaction mixture was concentrated to remove the THF. The water was extracted with DCM (2x), and the combined organic layers were dried over sodium sulfate, filtered, and concentrated to give The organic solvent was dried with anhydrous Na2SO4, concentrated by reduce pressure to give tert-butyl ((6-chloropyridazin-3- yl)methyl)carbamate (460 mg).

References: [1]Patent: WO2018/17983,2018,A1 .Location in patent: Paragraph 00239-00240.

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Precautionary Statements-General
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
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H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
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H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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H314	Causes severe skin burns and eye damage
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H318	Causes serious eye damage
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H320	Causes eye irritation
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H361d	Suspected of damaging the unborn child
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H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

CAS No. :	1454908-27-0
Formula :	C₁₀H₁₄ClN₃O₂
M.W :	243.69
SMILES Code :	O=C(OC(C)(C)C)NCC1=NN=C(Cl)C=C1

tert-Butyl ((6-chloropyridazin-3-yl)methyl)carbamate

CAS No.: 1454908-27-0

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Application In Synthesis [ 1454908-27-0 ]

[ 1454908-27-0 ] Synthesis Path-Downstream 1~1

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