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[ CAS No. 14548-51-7 ]

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Chemical Structure| 14548-51-7
Chemical Structure| 14548-51-7
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Product Details of [ 14548-51-7 ]

CAS No. :14548-51-7 MDL No. :MFCD09878790
Formula : C9H8BrNO Boiling Point : 359.1°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :226.07 g/mol Pubchem ID :27281844
Synonyms :

Safety of [ 14548-51-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 14548-51-7 ]

  • Upstream synthesis route of [ 14548-51-7 ]
  • Downstream synthetic route of [ 14548-51-7 ]

[ 14548-51-7 ] Synthesis Path-Upstream   1~4

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YieldReaction ConditionsOperation in experiment
42% With sodium azide; methanesulfonic acid In chloroform for 3 h; Reflux The compound 6-bromo-2,3-dihydro-1H-inden-1-one (2.0 g, 9.5 mmol) was dissolved in chloroform (30 mL)Methanesulfonic acid (6 mL) was then added dropwise to the reaction system,Finally, sodium azide (1.90 g, 9.5 mmol) was added portionwise to the reaction system,Reflux for three hours.After completion of the reaction, the mixture was cooled to room temperature, and then the reaction solution was poured into ice water. The mixture was separated and the aqueous phase was extracted with methylene chloride. The combined organic phases were dried over anhydrous sodium sulfate, filtered and dried. The crude product was purified by column chromatography (Petroleum ether / ethyl acetate: 2/1) to give 7-bromo-3,4-dihydroquinolin-2 (1H) -one(0.90 g) in 42percent yield.
Reference: [1] Patent: CN106349241, 2017, A, . Location in patent: Paragraph 0538; 0539; 0540; 0541; 0542
[2] Patent: WO2010/38901, 2010, A1, . Location in patent: Page/Page column 44
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 662 - 667
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Reference: [1] Chemische Berichte, 1880, vol. 13, p. 1680
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  • [ 501-52-0 ]
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Reference: [1] Chemische Berichte, 1880, vol. 13, p. 1680
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  • [ 114744-51-3 ]
Reference: [1] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 662 - 667
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