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Chemical Structure| 1451391-42-6 Chemical Structure| 1451391-42-6

Structure of 1451391-42-6

Chemical Structure| 1451391-42-6

3-Cyano-5-methylphenylboronic acid

CAS No.: 1451391-42-6

4.5 *For Research Use Only !

Cat. No.: A699201 Purity: 98%

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Product Details of [ 1451391-42-6 ]

CAS No. :1451391-42-6
Formula : C8H8BNO2
M.W : 160.97
SMILES Code : OB(C1=CC(C)=CC(C#N)=C1)O
MDL No. :MFCD18394418

Safety of [ 1451391-42-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 1451391-42-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1451391-42-6 ]

[ 1451391-42-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5419-55-6 ]
  • [ 124289-21-0 ]
  • [ 1451391-42-6 ]
YieldReaction ConditionsOperation in experiment
Preparation of further boronic acid and boronic ester intermediates.Preparation of intermediate 26, (3-cyano-5-methylphenyl)boronic acid3-Bromo-5-methylbenzonitrile (Intermediate 27, 250 mg, 1.28 mmol) was dissolved in THF (5 mL), cooled to -78 C and n-BuLi (1.19 mL of a 1.6 M solution in THF, 1.91 mmol) was added dropwise. After stirring at -78 C for 30 min triisopropyl borate (0.64 mL, 2.81 mmol) was added dropwise at -78 C, the cooling bath was removed and the reaction mixture was stirred at rt for 16 h. Saturated aqueous ammonium chloride solution (50 mL) and EtOAc (25 mL) were added and the phases were separated. The aqueous phase was extracted with EtOAc (2 x 25 mL), the combined organic phases were dried (Na2S04) and concentrated in vacuo to yield the crude title compound (200 mg) as an off-white solid which was used without further purification. Data in table 1.
 

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