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Chemical Structure| 1445968-07-9 Chemical Structure| 1445968-07-9

Structure of 1445968-07-9

Chemical Structure| 1445968-07-9

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Product Details of [ 1445968-07-9 ]

CAS No. :1445968-07-9
Formula : C6H3ClN2O
M.W : 154.55
SMILES Code : N#CC1=C(O)C=NC(Cl)=C1
MDL No. :MFCD28128848

Safety of [ 1445968-07-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:3439
Packing Group:

Application In Synthesis of [ 1445968-07-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1445968-07-9 ]

[ 1445968-07-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1060804-53-6 ]
  • [ 1445968-07-9 ]
YieldReaction ConditionsOperation in experiment
To a solution of aldehyde 21 a (4.4 g, 27.9 mmol, Anichem) in isopropyl alcohol (180 mL) is added hydroxylamine hydrochloride (5.8 g, 83.8 mmol). The solution is heated to reflux for 1 h, then cooled to RT and the solvent is removed in vacuo. The residue is diluted with EtOAc, washed with sodium bicarbonate solution and dried (Na2S04) to obtain the corresponding oxime. Cyanuric chloride (9.1 g, 49.3 mmol) is added portionwise to DMF (40 mL) at 0C while maintaining the temperature below 25C until cyanuric chloride completely consumed (~1 h). The obtained oxime is added to the solution of DMF at the same temperature and stirred for 1 h. The reaction mixture is quenched by adding water, extracted with EtOAc and washed with NaHC03 solution and brine. The organic layer is dried (Na2S04) and concentrated to give cyanide 21 b.
 

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