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Chemical Structure| 14436-32-9 Chemical Structure| 14436-32-9

Structure of 14436-32-9

Chemical Structure| 14436-32-9

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Product Details of [ 14436-32-9 ]

CAS No. :14436-32-9
Formula : C10H18O2
M.W : 170.25
SMILES Code : C=CCCCCCCCC(O)=O
MDL No. :MFCD00036663
InChI Key :KHAVLLBUVKBTBG-UHFFFAOYSA-N
Pubchem ID :61743

Safety of [ 14436-32-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 14436-32-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14436-32-9 ]

[ 14436-32-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 14436-32-9 ]
  • [ 4877-80-9 ]
  • 2,3,6,7,10,11-hexakis(non-8-enylcarbonyloxy)triphenylene [ No CAS ]
  • 2
  • [ 14436-32-9 ]
  • [ 5452-35-7 ]
  • [ 13850-91-4 ]
  • C23H42N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
26 mg The compound represented by the chemical formula (1) was obtained by the following procedure.34.5 mg (0.30 mmol) of cycloheptylamine was dissolved in 1 mL of methylene chloride,42 mg (0.18 mmol) of N-methyl-D-valine (Boc-N-Me-D-Val) having N terminal protected with Boc group, 54 mg (0.28 mmol) of EDCI · HCl, 36.5 mg mmol) were sequentially added, and finally 1 mL of dichloromethane was added and the mixture was stirred at room temperature for 4 hours.The reaction solvent was distilled off under reduced pressure, 20 mL of 1 M hydrochloric acid and 20 mL of ethyl acetate were added,Extraction was then carried out with ethyl acetate (2 × 20 mL).The organic layer was washed with 5% aqueous solution of sodium bicarbonate (20 mL)The organic layer was further dried with brine (20 mL), dried over anhydrous sodium sulfate, the desiccant was filtered, and the filtrate was concentrated under reduced pressure.And further dried with a vacuum pump to obtain a yellow oilDipeptide 1(30 mg, yield 51%).Next, 30 mg (0.092 mmol) of dipeptide 1 was dissolved in 2 mL of a 4 M hydrochloric acid / dioxane solution, stirred at room temperature for 3 hours, and the solvent was distilled off under reduced pressure to obtain a white powder from which the Boc group was removed.This white powder was dissolved in 1.0 mL of methylene chloride, and 39 mg (0.30 mmol) of diisopropylethylamine, 157 mg (0.30 mmol) of PyBOP,9-decenoic acid 17 mg (0.10 mmol) were sequentially added,Finally, 1 mL of dichloromethane was added and the mixture was stirred at room temperature for 14 hours.The reaction solvent was distilled off under reduced pressure, and 20 mL of 1 M hydrochloric acid and 20 mL of ethyl acetate were added for extraction.Further, the reaction solvent was distilled off under reduced pressure, 20 mL of 1 M hydrochloric acid and 20 mL of ethyl acetate were added, followed by extraction with ethyl acetate (2 × 20 mL).The organic layer was washed with 5% aqueous solution of sodium bicarbonate (20 mL), and the organic layer was further dried with brine (20 mL), dried over anhydrous sodium sulfate, filtered and the filtrate was distilled off under reduced pressure It was. Then, the remaining material was isolated and purified by silica gel chromatography (ethyl acetate: n-hexane = 4: 6) to obtain a compound represented by the chemical formula (1).(HPLC) [Inertsil, 250 × 20 mm, solvent ethyl acetate: n-hexane = 3: 7, flow rate: 2.0 mL / min (light yellow oil: 26 mg, yield 74%
 

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