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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 143782-18-7 Chemical Structure| 143782-18-7

Structure of 143782-18-7

Chemical Structure| 143782-18-7

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Product Details of [ 143782-18-7 ]

CAS No. :143782-18-7
Formula : C9H3F3N2O
M.W : 212.13
SMILES Code : N#CC1=CC=C(N=C=O)C=C1C(F)(F)F
MDL No. :MFCD20483372

Safety of [ 143782-18-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H331-H315-H318-H317-H334-H335
Precautionary Statements:P501-P261-P272-P270-P271-P264-P280-P284-P302+P352-P342+P311-P362+P364-P333+P313-P301+P310+P330-P304+P340+P311-P305+P351+P338+P310-P403+P233-P405
Class:6.1
UN#:2206
Packing Group:

Application In Synthesis of [ 143782-18-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 143782-18-7 ]

[ 143782-18-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 49851-36-7 ]
  • [ 143782-18-7 ]
  • C18H14F3N3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In tetrahydrofuran; at 20℃; 5.3 ml of a 20% solution of phosgene in toluene were initially charged under an argon atmosphere and admixed dropwise at 75 C. with a solution of 1 g of 4-amino-2-trifluoromethylbenzonitrile in 25 ml of dry acetonitrile; then the mixture was stirred at 75 C. for 2 h. The reaction mixture was concentrated under reduced pressure, taken up in toluene and concentrated again. The residue was dissolved in 20 ml of tetrahydrofuran and admixed with 1 g of <strong>[49851-36-7]methyl 2-aminophenylacetate hydrochloride</strong>. To this mixture were slowly added dropwise 1.05 ml of triethylamine with stirring and the reaction mixture was then stirred at room temperature for 8 h. Finally, 5 ml of concentrated hydrochloric acid were added and the mixture was heated under reflux for 8 h. Thereafter, the cooled reaction mixture was admixed cautiously with saturated sodium hydrogencarbonate solution. The mixture was extracted with ethyl acetate; the organic phase was dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by chromatography (method [RP1]). This afforded 120.1; molecular weight 345.07 (C17H10F3N3O2); retention time Rt=2.04 min. [B]; MS(ES-): 344.51 (M-H+).
 

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