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Chemical Structure| 14365-32-3 Chemical Structure| 14365-32-3

Structure of 14365-32-3

Chemical Structure| 14365-32-3

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Product Details of [ 14365-32-3 ]

CAS No. :14365-32-3
Formula : C6H11FO
M.W : 118.15
SMILES Code : O[C@H]1[C@H](F)CCCC1
MDL No. :MFCD08146648

Safety of [ 14365-32-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of [ 14365-32-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14365-32-3 ]

[ 14365-32-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 14365-32-3 ]
  • [ 694-82-6 ]
YieldReaction ConditionsOperation in experiment
45% With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -70 - 0℃; General procedure: To a solution of oxalyl chloride (2.9 g, 23 mmol) in 40 ml of methylene chloride were added dropwise 3.6 ml (50 mmol) of DMSO in 10 ml of methylene chloride at -70 C. The trans-2-halogencycloalkanol (20 mmol) was added and the reaction mixture was stirred for 20 min. The temperature was then raised to -55 C and 16 ml of triethylamine was added. The reaction mixture was stirred for 20 min, warmed to 0 C, and poured into a 1 M hydrochloric acid solution. The water phase was separated and extracted with methylene chloride, the combined organic phases were washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was distilled under vacuum. rac-5a: yield 65%, bp 110 С (10 mmHg).22a 1H NMR (500 MHz, CDCl3): δ 1.40 (m, 1H, CH2), 1.60 (m, 2H, CH2), 1.90 (m, 1H, CH2), 2.10-2.31 (m, 2H, CH2), 2.45 (m, 2H, CH2), 5.21 (m, 1H, CHI). rac-5d: yield 45%, bp 70 С (10 mmHg).22b rac-6a: yield 65%, bp 100 С (10 mmHg).22c rac-5b, rac-5c, rac-6b;22c were prepared by known methods.
  • 2
  • [ 14365-32-3 ]
  • [ 694-82-6 ]
  • 3
  • [ 694-82-6 ]
  • [ 14365-32-3 ]
  • (±)-cis-2-fluorocyclohexanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tetrahydroborate; In methanol; at 0 - 20℃; General procedure: (b) To halogencycloalkanones 5,6 (10 mmol) in 50 ml of methanol was added sodium borohydride (0.12 mol) at 0 С and the reaction mixture was stirred for 2 h at room temperature. Next, NH4Cl (11 mmol) was added and the reaction mixture was stirred for 0.5 h, filtered off, evaporated under reduced pressure, and the residue was extracted with methylene chloride. The extract was then dried over Na2SO4. The solvent was removed under reduced pressure and the residue was recrystallized from hexane. Spectroscopic data of 7b-d; 8b,c were in accordance with literature data.20-22
 

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