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Chemical Structure| 1430753-76-6 Chemical Structure| 1430753-76-6

Structure of 1430753-76-6

Chemical Structure| 1430753-76-6

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Product Details of [ 1430753-76-6 ]

CAS No. :1430753-76-6
Formula : C10H11BrFNO2
M.W : 276.10
SMILES Code : O=C(OC(C)(C)C)C1=NC(F)=CC=C1Br
MDL No. :MFCD27988089
InChI Key :XXVBLAQLDHKBSP-UHFFFAOYSA-N
Pubchem ID :89498209

Safety of [ 1430753-76-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1430753-76-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1430753-76-6 ]

[ 1430753-76-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1029689-82-4 ]
  • [ 1430753-76-6 ]
  • [ 1430750-38-1 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50.0℃; for 24.0h; To a solution of methyl l,2,3,4-tetrahydroisoquinoline-8-carboxylate hydrochloride (12.37 g) and Example 1.1.11 (15 g) in dimethyl sulfoxide (100 mL) was added N,N-diisopropylethylamine (12 mL). The mixture was stirred at 50C for 24 hours. The mixture was then diluted with ethyl acetate (500 mL), washed with water and brine, and dried over NaaSOzi. Filtration and evaporation of the solvent gave a residue that was purified by silica gel chromatography, eluting with 20% ethyl acetate in heptane, to give the title compound. MS (ESI) m/e 448.4 (M+H)+.
With N-ethyl-N,N-diisopropylamine; In hexane; dimethyl sulfoxide; at 50.0℃; for 24.0h; To a solution of <strong>[1029689-82-4]methyl 1,2,3,4-tetrahydroisoquinoline-8-carboxylate hydrochloride</strong> (12.37 g) and Example 1.4.4 (15 g) in dimethyl sulfoxide (100 mL) was added N,N-diisopropylethylamine (12 mL). The mixture was stirred at 50 C. for 24 hours. The mixture was diluted with ethyl acetate (500 mL), washed with water and brine, and dried over Na2SO4. After filtration and evaporation of the solvent, the crude material was purified via silica gel column chromatography, eluting with 20% ethyl acetate in hexane, to give the title compound. MS (ESI) m/e 448.4 (M+H)+.
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50.0℃; for 24.0h; [000516] To a solution of methyl l,2,3,4-tetrahydroisoquinoline-8-carboxylate hydrochloride (12.37 g) and Example 1.1.10 (15 g) in dimethyl sulfoxide (100 mL) was added N,N-diisopropylethylamine (12 mL), and the mixture was stirred at 50 C for 24 hours. The mixture was then diluted with ethyl acetate (500 mL) and washed with water and brine. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with 20% ethyl acetate in hexane, to give the title compound. MS (ESI) m/e 448.4 (M+H)+.
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50.0℃; for 24.0h; To a solution of methyl l,2,3,4-tetrahydroisoquinoline-8-carboxylate hydrochloride (12.37 g) and Example 1.4.4 (15 g) in dimethyl sulfoxide (100 mL) was added N,N-diisopropylethylamine(12 mL). The mixture was stirred at 50 C for 24 hours. The mixture was diluted with ethyl acetate (500 mL), washed with water and brine, and dried over Na2S04. After filtration and evaporation of the solvent, the crude material was purified via silica gel column chromatography, eluting with 20% ethyl acetate in hexane, to give the title compound. MS (ESI) m/e 448.4 (M+H)+.
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50.0℃; for 24.0h; To a solution of <strong>[1029689-82-4]methyl 1,2,3,4-tetrahydroisoquinoline-8-carboxylate hydrochloride</strong> (12.37 g) and Example 1.1.10 (15 g) in dimethyl sulfoxide (100 mL) was added N,N-diisopropylethylamine (12 mL), and the mixture was stirred at 50 oC for 24 hours. The mixture was then diluted with ethyl acetate (500 mL) and washed with water and brine. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with 20% ethyl acetate in hexane, to give the title compound. MS (ESI) m/e 448.4 (M+H)+.
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50.0℃; for 24.0h; To a solution of <strong>[1029689-82-4]methyl 1,2,3,4-tetrahydroisoquinoline-8-carboxylate hydrochloride</strong> (12.37 g) and Example 1.1.10 (15 g) in dimethyl sulfoxide (100 mL) was added N,N-diisopropylethylamine (12 mL), and the mixture was stirred at 50 C. for 24 hours. The mixture was then diluted with ethyl acetate (500 mL) and washed with water and brine. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with 20% ethyl acetate in hexane, to give the title compound. MS (ESI) m/e 448.4 (M+H)+.
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 50.0℃; for 24.0h; To a solution of <strong>[1029689-82-4]methyl 1,2,3,4-tetrahydroisoquinoline-8-carboxylate hydrochloride</strong> (12.37 g) and Example 1.1.11 (15 g) in dimethyl sulfoxide (100 mL) was added N,N-diisopropylethylamine (12 mL). The mixture was stirred at 50 C. for 24 hours. The mixture was then diluted with ethyl acetate (500 mL), washed with water and brine, and dried over Na2SO4. Filtration and evaporation of the solvent gave a residue that was purified by silica gel chromatography, eluting with 20% ethyl acetate in heptane, to give the title compound. MS (ESI) m/e 448.4 (M+H)+.

 

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