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Chemical Structure| 143007-15-2 Chemical Structure| 143007-15-2

Structure of 143007-15-2

Chemical Structure| 143007-15-2

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Product Details of [ 143007-15-2 ]

CAS No. :143007-15-2
Formula : C8H3ClF2N2
M.W : 200.57
SMILES Code : FC1=C(F)C=C2N=CC(Cl)=NC2=C1
MDL No. :MFCD11518958
InChI Key :BJQGARNEDBXHQC-UHFFFAOYSA-N
Pubchem ID :10375543

Safety of [ 143007-15-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 143007-15-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 143007-15-2 ]

[ 143007-15-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 475105-35-2 ]
  • [ 143007-15-2 ]
  • [ 475105-64-7 ]
YieldReaction ConditionsOperation in experiment
In DMF (N,N-dimethyl-formamide); at 90℃; for 120.0h; The amine D4 (0.607g), and 2-chloro-6, 7-difluoroquinoxaline McQuaid et. al. J. Med. Chem. (1992), 35 (18), 3319-24 (0.569g) were DISSOLVED IN DIMETHYLFORMAMIDE (LML) and heated to 90 C for 5 days under an atmosphere of argon. After cooling, the reaction solution was partitioned between ethyl acetate and water. The organic layer was washed with water, saturated brine, dried and evaporated. The residue was chromatographed over silica gel, eluting with a gradient of 10 to 50% ethyl acetate in hexane. The title compound was obtained as a pale yellow solid (0.460g), MHF 379. CLGH24F2N402 requires 378.
In DMF (N,N-dimethyl-formamide); at 90℃; for 120.0h; Description 7 : (S)-2-[(6, 7-DIFLUOROQUINOXALIN-2-YLAMINO) METHYL]-PIPERIDINE-1- carboxylic acid tert buty ester The amine D4 (0.607g), and 2-chloro-6, 7-difluoroquinoxaline McQuaid et. AL. J MED. Chem. (1992), 35 (18), 3319-24 (0.569g) were dissolved in dimethylformamide (LML) and heated to 90 C for 5 days under an atmosphere of argon. After cooling, the reaction solution was partitioned between ethyl acetate and water. The organic layer was washed with water, saturated brine, dried and evaporated. The residue was chromatographed over silica gel, eluting with a gradient of 10 to 50% ethyl acetate in hexane. The title compound was obtained as a pale yellow solid (0.460g), MET 379. CL9H24F2N402 requires 378.
 

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