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Chemical Structure| 1429180-77-7 Chemical Structure| 1429180-77-7

Structure of 1429180-77-7

Chemical Structure| 1429180-77-7

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Product Details of [ 1429180-77-7 ]

CAS No. :1429180-77-7
Formula : C13H10ClN3O2
M.W : 275.69
SMILES Code : O=C1OC[C@@H](C2=CC=CC=C2)N1C3=NC(Cl)=NC=C3
MDL No. :MFCD30183458

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Application In Synthesis of [ 1429180-77-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1429180-77-7 ]

[ 1429180-77-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1429180-77-7 ]
  • [ 74877-07-9 ]
  • [ 1429176-38-4 ]
  • [ 1429176-39-5 ]
YieldReaction ConditionsOperation in experiment
In dimethyl sulfoxide; at 110℃; for 1.5h; Examples 193 and 194A solution of (R)-3-(2-chloropyrimidin-4-yl)-4-phenyloxazolidin-2-one (83 mg, 0.30 mmol) and 1-(3,4-dichlorophenyl)ethanamine (260 mg, 1.37 mmol, 4.5 equiv) in DMSO (1.5 mL) was heated at 1 10 C for 1 ? h. The reaction mixture was diluted with EtOAc (8 mL) and washed with water (30 mL). After separation, the aqueous phase was extracted with EtOAc (3 x 8 mL). Combined organics were dried over Na2S04, filtered and concentrated. Silica gel column chromatography (EtO Ac/ Heptane 0 to 40%) provided (R)-3-(2-((/?)-1-(3,4-dichlorophenyl)ethylamino)pyrimidin-4-yl)-4-phenyloxazolidin-2-one and (R)-3-(2-((S)-1-(3,4-dichlorophenyl)ethylamino)pyrimidin-4-yl)-4-phenyloxazolidin-2- one.Example 193 first eluted product (13 mg) 1H NMR (400 MHz, CD3OD) ? 8.1 1 (d, J = 5.6 Hz, 1 H), 7.44 - 7.38 (m, 5 H), 7.35 - 7.31 (m, 1 H), 7.27 - 7.25 (m, 2 H), 7.18 (dd, J = 8.3, 2.3 Hz, 1 H), 5.53 (dd, J = 8.8, 3.8 Hz, 1 H), 4.76 (t, J = 8.8 Hz, 1 H), 4.59 - 4.53 (m, 1 H), 4.18 (dd, J = 8.8, 4.3 Hz, 1 H), 1.22 (d, J = 7.1 Hz, 3 H); HRMS(B) m/z 429.0899 (M + H)+.Example 194 second eluted product (26 mg) 1 H NMR (400 MHz, CD3OD) ? 8.13 (d, J = 5.6 Hz, 1 H), 7.41 (d, J = 6.1 Hz, 1 H), 7.25 - 7.18 (m, 5 H), 7.09 - 7.06 (m, 2 H), 6.95 - 6.93 (m, 1 H), 5.78 (dd, J = 8.6, 3.5 Hz, 1 H), 4.89 (q, J = 6.7 Hz, 1 H), 4.79 (t, J = 8.6 Hz, 1 H), 4.18 (dd, J = 8.8, 3.8 Hz, 1 H), 1 .42 (d. J = 7.1 Hz, 3 H); HRMS(B) m/z429.0887 (M + H)+.
 

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