142733-65-1|(cis-3-Aminocyclobutyl)methanol hydrochloride| Ambeed

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Quality Control of [ 142733-65-1 ] Purity: 97% SDS Specification

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Product Details of [ 142733-65-1 ]

CAS No. :	142733-65-1
Formula :	C₅H₁₂ClNO
M.W :	137.61
SMILES Code :	OC[C@H]1C[C@@H](N)C1.[H]Cl
MDL No. :	MFCD16660356
InChI Key :	NGVZDZFNCCGDGQ-UHFFFAOYSA-N
Pubchem ID :	19794279

Safety of [ 142733-65-1 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Application In Synthesis of [ 142733-65-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 142733-65-1 ]

[ 142733-65-1 ] Synthesis Path-Downstream 1~16

1
[ 142733-64-0 ]
[ 142733-65-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20.0℃;	To a solution of tert-butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate (0.154 g, 0.765 mmol) in DCM (2 mL), HC1 4N in dioxane (0.4 mL, 1.6 mmol) was added at rt. After 5h30 min a further aliquot of HC1 4N in dioxane (0.8 mL, 3.2 mmol) was added and mixture was left at rt until complete conversion. Mixture was evaporated under reduced pressure to obtain cis- 3- (hydroxymethyl)cyclobutan-l-aminium chloride as a white solid (128 mg). Method 1 : Rt=0.83 min, m/z=l02 (M+H)+. The crude compound (38.5 mg, 0.280 mmol) was taken in dry acetonitrile (1.7 mL) and dry DIPEA (0.1 mL, 0.574 mmol) and ethyl 4-(chlorosulfonyl)-3-fluoro-l-methyl- lH-pyrrole-2-carboxylate (50 mg, 0.185 mmol) were added at room temperature. Reaction mixture was stirred overnight and then evaporated under reduced pressure to afford a light brown solid. Crude was purified with flash chromatography (Petroleum ether/ AcOEt) to afford D42 as a white solid (45 mg) m/z = 335 (M+H)+.

References: [1]Heterocycles,1992,vol. 34,p. 739 - 745.
[2]Patent: WO2020/30781,2020,A1 .Location in patent: Page/Page column 67-68.

2
[ 142733-65-1 ]
[ 142733-66-2 ]