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Chemical Structure| 1424-22-2 Chemical Structure| 1424-22-2

Structure of 1424-22-2

Chemical Structure| 1424-22-2

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Product Details of [ 1424-22-2 ]

CAS No. :1424-22-2
Formula : C8H12O2
M.W : 140.18
SMILES Code : CC(OC1=CCCCC1)=O
MDL No. :MFCD00013774
InChI Key :DRJNNZMCOCQJGI-UHFFFAOYSA-N
Pubchem ID :74019

Safety of [ 1424-22-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335-H227
Precautionary Statements:P210-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of [ 1424-22-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1424-22-2 ]

[ 1424-22-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1424-22-2 ]
  • [ 694-82-6 ]
YieldReaction ConditionsOperation in experiment
With fluorine; In acetonitrile; EXAMPLE 1 Through a stirred solution of 1-cyclohexenyl acetate (3.5 gm, 25 mmol) in dry acetonitrile (50 ml) was bubbled fluorine (50 mmol diluted to 10% v/v with nitrogen) over 110 mins. The reaction temperature was maintained at about 0 C. by cooling the reaction vessel externally. When the reaction was complete, the fluorine was switched off and the vessel was purged with nitrogen. The reaction mixture was then poured into water and thoroughly shaken before being extracted with dichloromethane. Most of the solvent was removed from the dried extracts under reduced pressure using a rotary evaporator. The residue was then distilled under reduced pressure using a short path distillation apparatus to give a main fraction (2.3 gm) which contained one major component (77% of total area of chromatogram) and several minor ones. A sample of the main component was isolated by preparative scale gas chromatography and identified as 2-fluorocyclohexanone (19 F NMR δ-188.7 ppm, d, JHF 48.7 Hz. 1 H NMR δ 4.96 ppm, dq, JHF 49 Hz, JHH 5.9 Hz, Multiplets at 2.6, 2.4, 2.1 and 1.7 ppm, M+ 116). Yield of 2-fluorocyclohexanone=61%.
  • 2
  • [ 1424-22-2 ]
  • [ 694-82-6 ]
  • [ 108-94-1 ]
  • 3
  • [ 221044-05-9 ]
  • [ 1424-22-2 ]
  • 2-(cyclohex-1-en-1-yl)-1-(pyrimidin-2-yl)-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With 1,4-bis[2,6-di(2-propyl)phenyl]-3-phenyl-1H-1,2,4-triazol-4-ium chloride; cyclohexylmagnesiumchloride; cobalt(II) iodide; In tetrahydrofuran; at 23℃; for 16h;Inert atmosphere; General procedure: To a solution of 2a (49.5 mg, 0.25 mmol, 1.0 equiv), CoI2 (7.8 mg, 25.0 μmol, 10 mol%) and triazolium salt 1h (13.1 mg, 25.0 μmol, 10 mol%) in DMPU (1.5 mL) was added alkenyl acetate 3a (78.5 mg, 0.38 mmol, 1.5 equiv, E/Z = 24:76), then CyMgCl (1.7 m in THF, 0.3 mL, 0.5 mmol, 2.0 equiv) was added dropwise over 10 min. The mixture was stirred for 16 h at 23 C, then saturated aq. NH4Cl solution (10 mL) was added. The mixture was extracted with CH2Cl2 (3 × 5 mL), dried over Na2SO4 and concentrated in vacuo. Column chromatography on silica gel (n-pentane/EtOAc, 25:1) gave 4aa.
 

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