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Chemical Structure| 1423078-56-1 Chemical Structure| 1423078-56-1

Structure of 1423078-56-1

Chemical Structure| 1423078-56-1

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Product Details of [ 1423078-56-1 ]

CAS No. :1423078-56-1
Formula : C12H16BN3O2
M.W : 245.09
SMILES Code : CC1(C)C(C)(C)OB(C2=C3C=CC=NN3N=C2)O1
MDL No. :MFCD18072640

Safety of [ 1423078-56-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1423078-56-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1423078-56-1 ]

[ 1423078-56-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 171879-99-5 ]
  • [ 1423078-56-1 ]
  • 3-(6-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-b]pyridazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
37% With methanesulfonic acid(2-dicyclohexylphosphino-2?,4?,6?-triisopropyl-1,1?-biphenyl)[2-(2?-amino-1,1?-biphenyl)]palladium(II); In ethanol; water; at 140℃; for 0.5h;Microwave irradiation; A mixture of 4-chloro-6-methyl-1 H-pyrrolo[2,3-b]pyridine (47mg, 0.291 mmol), 3-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyrazolo[1 ,5-b]pyridazine (107mg, 0.436mmol), X Phos Pd G3 (19.6mg, 0.023mmol) and potassium phosphate (124mg, 0.582mmol) in degassed ethanol (3.0ml_) and water (1.5ml_) was heated at 140C for 30 mins in the microwave. After cooling it was partitioned between ethyl acetate and water and the organic layer was separated, washed with brine, dried (Na2S04) and concentrated in vacuo. The crude product was purified by MDAP (Basic) to afford the title compound as a glass (27mg, 37%) LCMS (Method 1): Rt 2.12 min, m/z 249.8 [MH+]. 1 H NMR (400 MHz, d6-DMSO): 2.59 (3H, s), 6.56 (1 H, d, J=3.5 Hz), 7.19 (1 H, s), 7.34 (1 H, dd, J=4.4, 9.1 Hz), 7.43 (1 H, d, J=3.5 Hz), 8.48 (1 H, dd, J=1.8, 9.2 Hz), 8.56- 8.58 (2H, m), 11.59 (1 H, s)
 

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