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Chemical Structure| 142168-97-6 Chemical Structure| 142168-97-6

Structure of 142168-97-6

Chemical Structure| 142168-97-6

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Product Details of [ 142168-97-6 ]

CAS No. :142168-97-6
Formula : C7H4BrN3O2
M.W : 242.03
SMILES Code : O=C1NC2=NC=C(Br)C=C2C(N1)=O

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Application In Synthesis of [ 142168-97-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 142168-97-6 ]

[ 142168-97-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 142168-97-6 ]
  • [ 1234616-70-6 ]
YieldReaction ConditionsOperation in experiment
80% With trichlorophosphate; In N,N-dimethyl-formamide; for 6.0h;Reflux; General procedure: 2,4,6-Trichloro-pyrido[2,3-d]pyrimidine (6) (C7H2Cl3N3): A mixture of 50 mL of POCl3, two drops of DMF, and 5 g of 6-chloro-1H-pyrido[2,3-d]pyrimidine-2,4-dione 4 were heated to reflux. After 6 h, the reaction was evaporated under reduced pressure; 400 mL of CH2Cl2 and 20 mL of water were added to the residue at C. The aqueous phase was extracted, the organic layers were combined and then dried over magnesium sulfate. After filtration the filtrate was evaporated under reduced pressure, and then washed with Et2O to obtain compound 6 as a yellow solid in 64% yield.
  • 2
  • [ 142168-97-6 ]
  • [ 1234616-70-6 ]
YieldReaction ConditionsOperation in experiment
64% With N,N-diethylaniline; trichlorophosphate; at 110.0℃; for 5.0h; Prepared from13 (1.02?g, 4.23?mmol) by general procedure C. Yellow solid (755.1?mg, 64%). 1H NMR (CDCl3) delta?=?8.75 (d, 1H, J?=?2.5?Hz), 9.30 (d, 1H, J?=?2.5?Hz). MS (ESI) 279.8 (M+H)+.
 

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