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Chemical Structure| 14203-25-9 Chemical Structure| 14203-25-9

Structure of 14203-25-9

Chemical Structure| 14203-25-9

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Product Details of [ 14203-25-9 ]

CAS No. :14203-25-9
Formula : C6H7BrO2
M.W : 191.02
SMILES Code : COC(CC1)=C(Br)C1=O
MDL No. :MFCD11044009

Safety of [ 14203-25-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 14203-25-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14203-25-9 ]

[ 14203-25-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 865139-18-0 ]
  • [ 14203-25-9 ]
  • [ 1237529-57-5 ]
YieldReaction ConditionsOperation in experiment
With potassium phosphate;dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In toluene; at 90℃; for 4h;Inert atmosphere; Example 5; Preparation of 2-r4-(6-chloroquinolin-2-yloxy)-2,6-dimethylphenyl1-4-(tetrahvdropyran-4- ylmethyl)cvclopentane-1 ,3-dioneStep 1 : Preparation of 2-(4-benzyloxy-2,6-dimethylphenyl)-3-methoxycyclopent-2-enoneTo a suspension of 2-bromo-3-methoxycyclopent-2-enone (5.0Og, 26.0mmol), 4-benzyloxy-2,6- dimethylphenyl boronic acid (7.2Og, 28mmol) (described in EP1726580) and potassium phosphate (9.55g, 45mmol) in degassed toluene (125ml) is added palladium (II) acetate (0.135g, O.deltammol) and 2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl (0.492g, 1.2mmol). The reaction mixture is then heated at 90 0C under a nitrogen atmosphere for 4 hours, then allowed to cool to room temperature. After partitioning between ethyl acetate (500 ml) and distilled water (500 ml), the organic phase is separated and concentrated in vacuo. The crude product is purified by flash column chromatography (ethyl acetate/hexane eluant) to afford 2-(4-benzyloxy-2,6- dimethylphenyl)-3-methoxycyclopent-2-enone as a white solid.
 

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