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Chemical Structure| 1417190-31-8 Chemical Structure| 1417190-31-8

Structure of 1417190-31-8

Chemical Structure| 1417190-31-8

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Product Details of [ 1417190-31-8 ]

CAS No. :1417190-31-8
Formula : C8H6FIO2
M.W : 280.04
SMILES Code : O=C(O)C1=C(I)C=CC(F)=C1C
MDL No. :MFCD28139917

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Application In Synthesis of [ 1417190-31-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1417190-31-8 ]

[ 1417190-31-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1417190-31-8 ]
  • [ 80-48-8 ]
  • [ 1262417-94-6 ]
  • 2
  • [ 67-56-1 ]
  • [ 1417190-31-8 ]
  • [ 1262417-94-6 ]
YieldReaction ConditionsOperation in experiment
To a solution of 3-fluoro-6-iodo-2-methylbenzoic acid i-lOa (3.7 g, 13.2 mmol) in DCM (30 mL) were added oxalyl dichloride (5.0 g, 39.6 mmol) and DMF (48 mg, 0.66 mmol). The mixture was stirred at room temperature for 0.5 h, then concentrated. The residue was dissolved in methanol (40 mL) and the mixture was stirred at room temperature for 18 h. The mixture was concentrated and the residue was purified by flash chromatography (1:20EtOAc/hexanes) to give the title compound as a solid. ?H NMR (400 MHz, CDC13) oe 7.60 (dd, J= 8.2 Hz, 5.1 Hz, 1H), 6.82 (t,J= 8.8 Hz, 1H), 3.96 (s, 3H), 2.24 (s, 3H).
 

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