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Chemical Structure| 1415220-35-7 Chemical Structure| 1415220-35-7

Structure of 1415220-35-7

Chemical Structure| 1415220-35-7

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Product Details of [ 1415220-35-7 ]

CAS No. :1415220-35-7
Formula : C7H6BrN3
M.W : 212.05
SMILES Code : CC1=C2C(NC=C2Br)=NC=N1
MDL No. :MFCD27987885

Safety of [ 1415220-35-7 ]

Application In Synthesis of [ 1415220-35-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1415220-35-7 ]

[ 1415220-35-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 945950-37-8 ]
  • [ 1415220-35-7 ]
  • 2
  • [ 1415220-35-7 ]
  • [ 163226-45-7 ]
  • [ 1415220-39-1 ]
  • 3
  • [ 1415220-35-7 ]
  • [ 163226-45-7 ]
  • C35H32BrN3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃; for 2h;Inert atmosphere; General procedure: To a mixture of appropriate 3a-e (1.5 mmol), 1 (1.57 mmol) and Ph3P (3.75 mmol) in THF was added DIAD (3.75 mmol) dropwise at 0 C under nitrogen and stirring continued at rt. Completion of reaction was analyzed by TLC, solvent evaporated under reduced pressure and crude was purified by column chromatography on silica gel by eluting up to 30 % ethyl acetate in hexane to give couple products in more than 80 % yield. The deprotection was carried out by heating at 60 C in 10 % HCl in MeOH. After completion (monitored by TLC), the reaction mixture was neutralized by NaHCO3 and purified by silica gel chromatography (10% methanol in DCM) to get 6a-e in 70-85% yield.
 

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