141492-94-6|2-Iodo-6-(trifluoromethyl)pyrazine| Ambeed

Yield	Reaction Conditions	Operation in experiment
	With iodine; copper; In chloroform;	(a) 2-Iodo-6-trifluoromethylpyrazine A three liter flask was charged with a solution of <strong>[69816-35-9]2-amino-6-trifluoromethylpyrazine</strong> (obtained by the method of J. L. Miesel, U.S. Pat. No. 4,293,552, 95% pure by HPLC analysis, 32.6 g, 0.20 mol) in chloroform (1000 mL). Freshly ground iodine (101 g. 0.40 mol) was added to give a dark purple solution. After 40 min, a solution of t-butyl nitrite (22.9 g, 0.20 mol) in chloroform (300 mL) was added dropwise over 1 h. During the addition, slow gas evolution was observed together with a mild exotherm (<10 C.) which was moderated with a cold water bath. After an additional 1 h at room temperature the reaction mixture was washed with saturated aqueous sodium sulfite (3*500 mL) to remove the excess iodine. The chloroform solution was dried over magnesium sulphate, filtered and concentrated on a Buchi to give 23 g of an orange oil. The crude product was purified by distillation from copper (40-80 mesh, 200 mg) to give 19.5 g of the title compound as a yellow oil; b.p. 50-56 C./0.6 mmHg; delta (360 MHz, CDCl3) 9.06 (1H, s, pyrazine-H), 8.86 (1H, s, pyrazine-H); m/e 274 (M+).
	With iodine; In chloroform;	(a) 2-Iodo-6-trifluoromethylpyrazine A three litre flask was charged with a solution of <strong>[69816-35-9]2-amino-6-trifluoromethylpyrazine</strong> (obtained by the method of J.L. Miesel, U.S. Patent 4293552, 95% pure by HPLC analysis, 32.6g, 0.20mol) in chloroform (1000mL). Freshly ground iodine (101g. 0.40mol) was added to give a dark purple solution. After 40 min, a solution of t-butyl nitrite (22.9g, 0.20mol) in chloroform (300mL) was added dropwise over 1h. During the addition, slow gas evolution was observed together with a mild exotherm (< 10C) which was moderated with a cold water bath. After an additional 1h at room temperature the reaction mixture was washed with saturated aqueous sodium sulfite (3 x 500mL) to remove the excess iodine. The chloroform solution was dried over magnesium sulphate, filtered and concentrated on a Buchi to give 23g of an orange oil. The crude product was purified by distillation from copper (40-80 mesh, 200mg) to give 19. 5g of the title compound as a yellow oil; b.p. 50-56C/0.6mmHg; delta (360MHz, CDCl3) 9.06 (1H, s, pyrazine-H), 8.86 (1H, s, pyrazine-H); m/e 274 (M+).

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2-Iodo-6-(trifluoromethyl)pyrazine

CAS No.: 141492-94-6

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Product Details of [ 141492-94-6 ]

Safety of [ 141492-94-6 ]

Application In Synthesis of [ 141492-94-6 ]

[ 141492-94-6 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
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H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
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H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed