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Chemical Structure| 1394820-97-3 Chemical Structure| 1394820-97-3

Structure of 1394820-97-3

Chemical Structure| 1394820-97-3

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Product Details of [ 1394820-97-3 ]

CAS No. :1394820-97-3
Formula : C22H15FN2O4
M.W : 390.36
SMILES Code : O=[N+](C1=CC=C(OC2=CC=NC3=CC(OCC4=CC=CC=C4)=CC=C23)C(F)=C1)[O-]
MDL No. :MFCD28142878

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1394820-97-3 ]

[ 1394820-97-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1394820-97-3 ]
  • [ 1394820-98-4 ]
YieldReaction ConditionsOperation in experiment
85% With hydrogenchloride; water; In 1,4-dioxane; at 100℃; for 24h; Step 5) 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol A suspension of 7-(benzyloxy)-4-(2-fluoro-4-nitrophenoxy)quinoline (100 g, 256.4 mmol) in dioxane (425 mL) and conc. HCl (425 mL, 5.1 mol) was stirred at 100 C. for 24 hours. The reaction mixture was then cooled to room temperature and solid was collected through filtration. The solid was then suspended in anhydrous EtOH (100 mL) and stirred for 2 hours. The solid was collected and dried in vacuo at 60 C. for 12 hours to give the title compound as a pale solid (73.3 g, 85%). MS (ESI, pos. ion) m/z: 301 [M+1]; 1H NMR (400 MHz, DMSO-d6): delta 7.06-7.07 (d, J=6.8 Hz, 1H), 7.51-7.54 (m, 1H), 7.71 (s, 1H), 7.89-7.94 (m, 1H), 8.28-8.30 (d, J=8.8 Hz, 1H), 8.41-8.43 (d, J=9.6 Hz, 1H), 8.51-8.54 (d, J=10 Hz, 1H), 8.94-8.96 (d, J=6.4 Hz, 1H), 12.00 (s, 1H).
 

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