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Structure of 1394291-51-0

Chemical Structure| 1394291-51-0

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Product Details of [ 1394291-51-0 ]

CAS No. :1394291-51-0
Formula : C7H6BrFO
M.W : 205.02
SMILES Code : OC1=C(F)C=C(C)C=C1Br
MDL No. :MFCD22543672
InChI Key :PFMAUMFDMPLSPL-UHFFFAOYSA-N
Pubchem ID :57699567

Safety of [ 1394291-51-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 1394291-51-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1394291-51-0 ]

[ 1394291-51-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1394291-51-0 ]
  • [ 185345-46-4 ]
YieldReaction ConditionsOperation in experiment
88% With oxygen; cobalt(II) diacetate tetrahydrate; sodium hydroxide; In ethylene glycol; at 80.0℃; under 760.051 Torr; for 8.0h; General procedure: a mixture of substrate 1a(1 mmol), cobalt salt (n1mol%) and NaOH (n2 equiv)in EG (5 mL) was stirred with O2 (1 atm) being bubbled, under 80 oCfor 8 h. Hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were successively added to the reactionmixture. The organic layer was separated, and the aqueous phase was furtherextracted with MTBE(10 mL × 2). The combined organic phase was dried over anhydrous sodium sulfateand concentrated to give a residue, which was purified by column chromatographyon silica gel (eluents: petroleum ether/ethyl acetate, 10/1) to provide thedesired products 2a.
 

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