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Chemical Structure| 139-13-9 Chemical Structure| 139-13-9
Chemical Structure| 139-13-9

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Synonyms: Triglycollamic acid

4.5 *For Research Use Only !

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Product Details of Nitrilotriacetic acid

CAS No. :139-13-9
Formula : C6H9NO6
M.W : 191.14
SMILES Code : O=C(O)CN(CC(O)=O)CC(O)=O
Synonyms :
Triglycollamic acid
MDL No. :MFCD00004287
InChI Key :MGFYIUFZLHCRTH-UHFFFAOYSA-N
Pubchem ID :8758

Safety of Nitrilotriacetic acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H319-H350
Precautionary Statements:P281-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of Nitrilotriacetic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 139-13-9 ]

[ 139-13-9 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 139-13-9 ]
  • [ 3452-97-9 ]
  • nitrilotri-acetic acid tris-(3,5,5-trimethyl-hexyl ester) [ No CAS ]
  • 3
  • sodium [99Tc]pertechnetate [ No CAS ]
  • [ 139-13-9 ]
  • [ 5704-04-1 ]
  • (99m)Tc(HYNIC-Lys(OMe)-NIC)(tricine) [ No CAS ]
YieldReaction ConditionsOperation in experiment
> 95% With hydrogenchloride; tin(ll) chloride; In water; at 100℃; for 0.166667h;pH 5.0;Succinate buffer; [99mTc(HYNIC-Lys(OMe)-NIC)(<strong>[5704-04-1]tricin</strong>e)] To a sealed 5.0 mL vial were added 0.5 mL of HYNIC-Lys(OMe)-NIC solution (10 mug/mL) in 0.25 M succinate buffer (pH=5.0), and 0.2 mL of <strong>[5704-04-1]tricin</strong>e solution (100 mg/mL in 0.25 M succinate buffer, pH=5.0). After addition of 0.4 mL of 99mTcO4- solution (30 mCi) and 25 muL of SnCl2.2H2O solution (1.0 mg/mL in 0.1 N HCl), the mixture was heated in a water-bath at 100 C. for 10 minutes. After cooling to room temperature, a sample of the resulting solution was analyzed by radio-HPLC (Gradient I) and ITLC. The radiolabeling yield was >95%.
  • 4
  • [ 166737-85-5 ]
  • [ 139-13-9 ]
  • C72H69N7O6S3 [ No CAS ]
  • 5
  • [ 139-13-9 ]
  • [ 88333-03-3 ]
  • [ 17114-97-5 ]
  • [ 1443438-88-7 ]
  • 6
  • [ 50-00-0 ]
  • [ 139-13-9 ]
  • [ 88333-03-3 ]
  • [ 17114-97-5 ]
  • C57H81N7O15 [ No CAS ]
  • 7
  • [ 139-13-9 ]
  • [ 2439-54-5 ]
  • tris(N-methyl-N-n-octyl-2-ethylamide)amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
A separation reagent (C): tris(N-methyl-N-n-octyl-ethylamide)amine (amide-containing tertiaryamine represented by general formula (I) shown above in which R1=R2=R3=R4R5NC(O)R6, R4=CH3, R5=n-C8H17, and R6=CH2) was synthesized by the method shown below with reference to Journal of Molecular Structure, Vol. 657, pp. 177-183 (2003), the disclosure of which is incorporated by reference herein. (0121) Oxalyl chloride was added dropwise to nitrilotriacetic acid in benzene which contains a trace amount of dimethylformamide. After the mixture was stirred at room temperature for 6 hours, benzene and oxalyl chloride were removed under vacuum. The resulting solution was added to N-methyloctylamine in benzene, followed by stirring at 40° C. for 8 hours. The precipitate was filtered and the solvent was removed under vacuum. The crude product was purified by silica gel column chromatography (hexane:ethyl acetate=5:1) to give a separation reagent (C). (0122) The analytical results of the resultant separation reagent (C) are shown below. (0123) IR (neat, vcm?1): 1645 (C?O). (0124) Elementary analysis: Found: C=69.70percent; H=11.77percent; N=9.88percent. (0125) Calculated for C33H66N4O3: C=69.92percent; H=11.74percent; N=9.88percent. (0126) 1H-NMR (400 MHz, CDCl3, sigmappm): 0.87 (9H, 3CH2CH3); 1.2 to 1.4 (30H, 3NC2H4C5H10CH3); 1.5 (6H, 3CONCH2CH2CH2); 2.9 and 3.1 (9H, 3NCH3); 3.3 (6H, 3CONCH2CH2); 3.6 (6H, 3NCH2CO).
  • 8
  • [ 139-13-9 ]
  • [ 7474-78-4 ]
  • C24H21N7O9S3 [ No CAS ]
 

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