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Chemical Structure| 138964-51-9 Chemical Structure| 138964-51-9

Structure of 138964-51-9

Chemical Structure| 138964-51-9

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Product Details of [ 138964-51-9 ]

CAS No. :138964-51-9
Formula : C9H6BrNO2
M.W : 240.05
SMILES Code : O=C1NC2C=CC(Br)=CC=2C(=O)C1
MDL No. :MFCD29472381
InChI Key :DQFPMEMMMGZBKU-UHFFFAOYSA-N
Pubchem ID :54689446

Safety of [ 138964-51-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 138964-51-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 138964-51-9 ]

[ 138964-51-9 ] Synthesis Path-Downstream   1~21

  • 1
  • [ 138964-51-9 ]
  • [ 138964-54-2 ]
  • 2
  • [ 138964-51-9 ]
  • [ 138964-57-5 ]
  • 3
  • [ 669000-20-8 ]
  • [ 138964-51-9 ]
  • 4
  • [ 106-40-1 ]
  • [ 138964-51-9 ]
  • 5
  • [ 95262-09-2 ]
  • [ 138964-51-9 ]
  • 6
  • [ 138964-51-9 ]
  • (1s,4s)-4-((6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)amino)-N-methylcyclohexanecarboxamide [ No CAS ]
  • 7
  • [ 138964-51-9 ]
  • 6-bromo-4-((tetrahydro-2H-pyran-4-yl)amino)quinolin-2(1H)-one [ No CAS ]
  • 8
  • [ 138964-51-9 ]
  • 6-bromo-4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-quinolin-2(1H)-one [ No CAS ]
  • 9
  • [ 138964-51-9 ]
  • (1s,4s)-N-methyl-4-((2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4-yl)amino)cyclohexanecarboxamide [ No CAS ]
  • 10
  • [ 138964-51-9 ]
  • 4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)-quinolin-2(1H)-one [ No CAS ]
  • 11
  • [ 138964-51-9 ]
  • 4-(((1s,4s)-4-(2-methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-on [ No CAS ]
  • 12
  • [ 138964-51-9 ]
  • 6-bromo-4-chloroquinolin-2(1H)-one [ No CAS ]
  • 13
  • [ 138964-51-9 ]
  • [ 406204-90-8 ]
  • 14
  • [ 138964-51-9 ]
  • [ 762-42-5 ]
  • dimethyl 2-(6-bromo-4-oxo-1,4-dihydroquinolin-3-yl)fumarate [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With triethylamine; In ethanol;Reflux; General procedure: A suspension of 1,6-disubstituted quinoline-2,4-(1H,3H)-diones 1a-d (1 mmol) and dialkyl acetylenedicarboxylates2a,b (2 mmol) in 25 mL absolute ethanol and 0.5 mL oftriethylamine, was gently refluxed for 12-18 h (the reactionwas monitored by TLC). The resulting precipitateswere filtered off, dried and recrystallized from statessolvents.
  • 15
  • [ 138964-51-9 ]
  • [ 762-21-0 ]
  • ethyl 9-bromo-2,5-dioxo-5,6-dihydro-2H-pyrano[3,2-c]quinoline-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% With triethylamine; In ethanol;Reflux; General procedure: A suspension of 1,6-disubstituted quinoline-2,4-(1H,3H)-diones 1a-f (1 mmol) in 10 mL absolute ethanol wasadded to a solution of diethyl acetylenedicarboxylate (2a)(0.170 g, 1 mmol) in 15 mL absolute ethanol and 0.5 mLof triethylamine. The reaction mixture was gently refluxedfor 4-8 h, until the reactants had disappeared (monitoredby TLC). The resulting precipitates of 3a-f were filteredoff and dried. The precipitates were recrystallized fromsuitable solvents.
  • 16
  • [ 138964-51-9 ]
  • [ 762-21-0 ]
  • diethyl 2-(6-bromo-4-oxo-1,4-dihydroquinolin-3-yl)fumarate [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With triethylamine; In ethanol;Reflux; General procedure: A suspension of 1,6-disubstituted quinoline-2,4-(1H,3H)-diones 1a-d (1 mmol) and dialkyl acetylenedicarboxylates2a,b (2 mmol) in 25 mL absolute ethanol and 0.5 mL oftriethylamine, was gently refluxed for 12-18 h (the reactionwas monitored by TLC). The resulting precipitateswere filtered off, dried and recrystallized from statessolvents.
  • 17
  • [ 6623-89-8 ]
  • [ 138964-51-9 ]
  • 2'-amino-9'-bromo-2,5'-dioxo-5',6'-dihydrospiro[indoline-3,4'-pyrano-[3,2-c]quinolone]-3'-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With pyridine;Reflux; General procedure: A 100 cm3 round-bottom flask was flame-dried, a mixtureof 1a-1f (1 mmol), 2 (1 mmol), and 20 cm3 dry pyridinewas refluxed for 8-10 h with stirring (the reaction wasfollowed by TLC analysis). After the reaction’s completion,solvent was then removed under vacuum and theresidue was separated. The solid residue undergoesrecrystallization from the stated solvents to give purecrystals of spiro-compounds 3a-3f
  • 18
  • [ 138964-51-9 ]
  • C9H6BrCl2N [ No CAS ]
  • 19
  • [ 138964-51-9 ]
  • ethyl 5-amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-3-(methylthio)-1H-pyrazole-4-carboxylate [ No CAS ]
  • 20
  • [ 138964-51-9 ]
  • C9H8BrN3O [ No CAS ]
  • 21
  • [ 138964-51-9 ]
  • [ 81-07-2 ]
  • C16H9BrN2O4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% In propan-1-ol; water; at 125℃; for 8.0h; Put into 1000kg propanol water and stir in the reactor, add 183kg (1000mol) of saccharin successively, and then added 238.9kg (1000mol) of <strong>[138964-51-9]2-hydroxy-6-bromobenzopyridin-4-one</strong>, heated to 125C under pressure, and reacted under reflux for 8 hours, cool down and reduce pressure, steam to remove 600kg of reclaimed propanol, cool to 5C, and filter after standing for 12 hours to obtain yellow-brown product 4 379.6kg, yield 94%,
 

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