Home Cart Sign in  
Chemical Structure| 1386459-84-2 Chemical Structure| 1386459-84-2

Structure of 1386459-84-2

Chemical Structure| 1386459-84-2

(5-Bromo-3-chloro-2-fluorophenyl)methanamine

CAS No.: 1386459-84-2

4.5 *For Research Use Only !

Cat. No.: A1224626 Purity: 95%

Change View

Size Price

US Stock

Global Stock

In Stock
50mg łÇÊ˶ÊÊ Inquiry 1-2 weeks
100mg łÇÿǶÊÊ Inquiry 1-2 weeks
250mg łËÇď¶ÊÊ Inquiry 1-2 weeks

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • 50mg

    łÇÊ˶ÊÊ

  • 100mg

    łÇÿǶÊÊ

  • 250mg

    łËÇď¶ÊÊ

In Stock

- +

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1386459-84-2 ]

CAS No. :1386459-84-2
Formula : C7H6BrClFN
M.W : 238.48
SMILES Code : FC1=C(Cl)C=C(Br)C=C1CN
MDL No. :MFCD23163937

Safety of [ 1386459-84-2 ]

Application In Synthesis of [ 1386459-84-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1386459-84-2 ]

[ 1386459-84-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1000577-76-3 ]
  • [ 1386459-84-2 ]
YieldReaction ConditionsOperation in experiment
To a solution of <strong>[1000577-76-3]5-bromo-3-chloro-2-fluorobenzonitrile</strong> (13.2 g, 56.3 mmol) in THF (200 ml_) was added under an argon atmosphere a 1 M solution of boran-tetrahydrofuran-complex (70.4 ml_, 70.4 mmol) dropwise over 30 min. The reaction mixture was then heated at 65C for 1.5 h. After cooling to RT, a 2N HCI solution (70.4 ml_, 141 mmol) was added dropwise over 30 min. The reaction mixture was then again heated at 65C for 1 h and subsequently cooled to RT. Volatiles were evaporated and the residue was taken up in 1 M aqueous HCI solution, followed by extraction with EtOAc (3x150 ml_). The combined organics were washed with 1 M aqueous HCI solution. The combined acid phases were basified to pH=12 by addition of 4M aqueous NaOH solution and then extracted with EtOAc (3x150 ml_). The organics were dried (Na2S04), filtered and evaporated in vacuo to afford the title compound as a yellowish oil. MS (LC/MS): 238.0 [M+H]+; tR (HPLC conditions c): 3.25 min. The material thus obtained was used directly in the next step without further purification
  • 2
  • [ 1280786-80-2 ]
  • [ 1386459-84-2 ]
 

Historical Records