138165-75-0|3-((tert-Butoxycarbonyl)amino)-5-methylhexanoic acid| Ambeed

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Quality Control of [ 138165-75-0 ] Purity: 95% SDS Specification

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Product Details of [ 138165-75-0 ]

CAS No. :	138165-75-0
Formula :	C₁₂H₂₃NO₄
M.W :	245.32
SMILES Code :	CC(C)CC(NC(OC(C)(C)C)=O)CC(O)=O
MDL No. :	MFCD01076259

Safety of [ 138165-75-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H317
Precautionary Statements:	P280

Application In Synthesis of [ 138165-75-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 138165-75-0 ]

[ 138165-75-0 ] Synthesis Path-Downstream 1~35

1
[ 13139-15-6 ]
[ 138165-75-0 ]

References: [1]Tetrahedron Letters,1990,vol. 31,p. 7319 - 7322.
[2]Chemistry - A European Journal,2012,vol. 18,p. 6655 - 6662.
[3]Angewandte Chemie - International Edition,2014,vol. 53,p. 3594 - 3598.
Angew. Chem.,2014,vol. 126,p. 3668 - 3672,5.

2
[ 22818-43-5 ]
[ 24424-99-5 ]
[ 138165-75-0 ]

References: [1]Synthesis,1992,p. 1104 - 1108.

3
[ 138165-75-0 ]
[ 86834-95-9 ]

References: [1]Tetrahedron Letters,1990,vol. 31,p. 7319 - 7322.
[2]European Journal of Medicinal Chemistry,1997,vol. 32,p. 767 - 780.

4
[ 186581-53-3 ]
[ 13139-15-6 ]
[ 138165-75-0 ]

References: [1]European Journal of Medicinal Chemistry,1997,vol. 32,p. 767 - 780.
[2]Organic Syntheses,2002,vol. 79,p. 154 - 154.

5
[ 6638-79-5 ]
[ 138165-75-0 ]
[ 200949-36-6 ]

References: [1]European Journal of Medicinal Chemistry,1997,vol. 32,p. 767 - 780.

6
[ 138165-75-0 ]
(S)-3-tert-Butoxycarbonylamino-4-(1-formyl-1H-indol-3-yl)-butyric acid [ No CAS ]
(S)-3-[(S)-3-{(S)-3-[(S)-3-Amino-4-(1-formyl-1H-indol-3-yl)-butyrylamino]-5-methyl-hexanoylamino}-4-(1-formyl-1H-indol-3-yl)-butyrylamino]-5-methyl-hexanoic acid; compound with trifluoro-acetic acid [ No CAS ]

References: [1]Journal of the American Chemical Society,1998,vol. 120,p. 651 - 656.

7
[ 138165-75-0 ]
(S)-3-{(S)-3-[(S)-3-((S)-3-Amino-5-methyl-hexanoylamino)-5-methyl-hexanoylamino]-5-methyl-hexanoylamino}-5-methyl-hexanoic acid; compound with trifluoro-acetic acid [ No CAS ]

References: [1]Journal of the American Chemical Society,1998,vol. 120,p. 651 - 656.

8
[ 186581-53-3 ]
[ 138165-75-0 ]
[ 86834-94-8 ]
(S)-3-tert-Butoxycarbonylamino-5-methyl-hexanoic acid isobutyl ester [ No CAS ]
((S)-4-Diazo-1-isobutyl-3-oxo-butyl)-carbamic acid tert-butyl ester [ No CAS ]

References: [1]Helvetica Chimica Acta,1998,vol. 81,p. 983 - 1002.

9
[ 138165-75-0 ]
S-(+)-ethyl 3-amino-5,5-dimethylhexanoic acid hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,1998,vol. 6,p. 1707 - 1730.

10
[ 138165-75-0 ]
L-β-homoleucine hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,1998,vol. 6,p. 1707 - 1730.

11
[ 86834-94-8 ]
[ 138165-75-0 ]

References: [1]Chemistry - A European Journal,2012,vol. 18,p. 6655 - 6662.
[2]Bioorganic and Medicinal Chemistry,1998,vol. 6,p. 1707 - 1730.

12
[ 138165-75-0 ]
H-β³-hVal-OMe trifluoroacetic acid salt [ No CAS ]
[ 261722-51-4 ]

References: [1]Helvetica Chimica Acta,1999,vol. 82,p. 2067 - 2093.

13
{(S)-3-Methyl-1-[2-oxo-2-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-ethyl]-butyl}-carbamic acid tert-butyl ester [ No CAS ]
[ 138165-75-0 ]

References: [1]Angewandte Chemie - International Edition,2000,vol. 39,p. 1063 - 1066.

14
[ 138165-75-0 ]
N-carboxy-(S)-3-amino-5-methylhexanoic acid anhydride [ No CAS ]

References: [1]Organic Letters,2000,vol. 2,p. 1943 - 1946.

15
[ 52716-48-0 ]
[ 138165-75-0 ]

References: [1]Helvetica Chimica Acta,2002,vol. 85,p. 3313 - 3330.
[2]Organic Letters,2000,vol. 2,p. 1943 - 1946.
[3]Chemistry - A European Journal,2012,vol. 18,p. 6655 - 6662.

16
[ 33857-88-4 ]
[ 138165-75-0 ]
[ 500997-42-2 ]

References: [1]Helvetica Chimica Acta,2002,vol. 85,p. 3313 - 3330.

17
[ 557091-72-2 ]
[ 138165-75-0 ]

References: [1]Journal of the American Chemical Society,2003,vol. 125,p. 6846 - 6847.
[2]Journal of the American Chemical Society,2005,vol. 127,p. 5376 - 5383.

18
[ 2033-24-1 ]
[ 138165-75-0 ]
[ 653589-11-8 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 130 - 141.
[2]Angewandte Chemie - International Edition,2014,vol. 53,p. 3594 - 3598.
Angew. Chem.,2014,vol. 126,p. 3668 - 3672,5.

19
[ 138165-75-0 ]
[ 18107-18-1 ]
[ 86834-94-8 ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 9188 - 9189.

20
[ 748793-66-0 ]
[ 138165-75-0 ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 9188 - 9189.

21
[ 7154-73-6 ]
[ 138165-75-0 ]
[ 851968-52-0 ]

References: [1]Bioorganic and Medicinal Chemistry,2004,vol. 12,p. 4493 - 4509.

22
[ 1002750-54-0 ]
[ 138165-75-0 ]
((S)-3-methyl-1-{2-oxo-2-[4-(3-trifluoromethylbenzyloxyimino)piperidin-1-yl]ethyl}butyl)carbamic acid tert-butyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20℃; for 2h;	To a solution of piperidin-4-one O-(3-trifluoromethylbenzyl)oxime hydrochloride (247 mg, 0.80 mmol) and N-Boc-L-beta-homoleucine (216 mg, 0.88 mmol) in dichloromethane (4 ml), 1-hydroxybenzotriazole (108 mg, 0.80 mmol), N- ethyldimethylaminopropylcarbodiimide hydrochloride (184 mg, 0.96 mmol) and triethylamine (0.135 ml, 0.96 mmol) was added and stirred at room temperature for 2 hours. Saturated aqueous NaHCO3 solution (10 ml) was added, extracted with chloroform (20 ml x 2), dried (MgSO4) and evaporated under reduced pressure. The residue was purified by column chromatography on silica (ethyl acetate/hexane, 35/65- <n="390"/>60/40) to give ((S)-3-methyl-l-{2-oxo-2-[4-(3- trifluoromethylbenzyloxyimino)piperidin-l -yl] ethyl} butyl) carbamic acid ter t-bwtyl ester (340 mg, 85 %, colorless oil),

References: [1]Patent: WO2008/8398,2008,A2 .Location in patent: Page/Page column 388-389.

23
[ 67-56-1 ]
[ 138165-75-0 ]
methyl (S)-3-amino-5-methylhexanoate hydrochloride [ No CAS ]