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Chemical Structure| 1378866-33-1 Chemical Structure| 1378866-33-1

Structure of 1378866-33-1

Chemical Structure| 1378866-33-1

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Product Details of [ 1378866-33-1 ]

CAS No. :1378866-33-1
Formula : C8H9N3O
M.W : 163.18
SMILES Code : O=C1NC2=NC=C(N)C=C2CC1
MDL No. :N/A

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Application In Synthesis of [ 1378866-33-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1378866-33-1 ]

[ 1378866-33-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 475216-25-2 ]
  • [ 1378866-33-1 ]
  • N-methyl-3-nitro-4-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)amino]benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
19.7% With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120℃; for 12h; To a solution of 6-amino-3 ,4-dihydro- 1 H-i ,8-naphthyridin-2-one59 (1 .0 g) in N-methyl-2- pyrrolidinone (5 ml) were added 4-fluoro-N-methyl-3-nitro-benzamide2 (0.78 g) and N,Ndiisopropylethylamine (1.4 ml). The mixture was stirred at 120 C for 12 hours. The reaction mixture was then cooled to 20 C and poured into water. The resulting solid was collected by filtration, and the filter cake was washed with ethyl acetate and dried in vacuo to afford Nmethyl-3 -nitro-4- [(7-oxo-6, 8-dihydro-5H- 1, 8-naphthyridin-3 -yl)amino]benzamide (290 mg, 19.7%) as a brown solid. MS (ISP): 342.1 ([M+H]j.
 

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