13771-68-1|Ethyl 5-bromobenzo[b]thiophene-2-carboxylate| Ambeed

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Quality Control of [ 13771-68-1 ] Purity: 95% SDS Specification

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Product Details of [ 13771-68-1 ]

CAS No. :	13771-68-1
Formula :	C₁₁H₉BrO₂S
M.W :	285.16
SMILES Code :	O=C(C1=CC2=CC(Br)=CC=C2S1)OCC
MDL No. :	MFCD12756246
InChI Key :	QYNBPINLQQVHBJ-UHFFFAOYSA-N
Pubchem ID :	23261725

Safety of [ 13771-68-1 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P264-P271-P280-P312-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P501

Application In Synthesis of [ 13771-68-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 13771-68-1 ]

[ 13771-68-1 ] Synthesis Path-Downstream 1~35

1
[ 13771-68-1 ]
[ 13771-72-7 ]

Yield	Reaction Conditions	Operation in experiment
73%	With lithium borohydride; In tetrahydrofuran; at 60℃; for 3h;	(a) Tetrahydrofuran, LiBH4, 60 C., 3 h [0311] The substance was obtained according to the general procedure, yielding the title compound as a white solid (73%)

References: [1]Patent: US2014/303207,2014,A1 .Location in patent: Paragraph 0310; 0311.
[2]Journal of Medicinal Chemistry,1992,vol. 35,p. 457 - 465.
[3]RSC Advances,2016,vol. 6,p. 83448 - 83455.

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In acetonitrile; at 60℃;	General procedure: 2,4-Dichloro-6-fluorobenzaldehyde (300.0 mg, 1.6 mmol), ethyl mercaptoacetate (204 uL,1.9 mmol), Et3N (556 uL, 4.0 mmol) and CH3CN (10 mL) were added into a 50 ml round bottom flask, and stirred at 60 C for overnight. The CH3CN was removed in vacuo, and the residue was dissolved in ethyl acetate (30 ml) and water (10 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2x). The combined organics were dried (MgSO4) and concentrated to give title compound (397.3 mg, 87%).

3
[ 623-51-8 ]
[ 93777-26-5 ]
[ 13771-68-1 ]

Yield	Reaction Conditions	Operation in experiment
75%	With triethylamine; In dimethyl sulfoxide; at 95℃; for 2h;	(a) Ethyl thioglycolate, Et3N, DMSO, 95 C., 2 h [0304] The substance was obtained according to the general procedure, yielding the title compound as a off-white crystals (75%). [0305] 1H-NMR (400 MHz, DMSO-d6); δ (ppm): 1.33 (t, 3H), 4.36 (dd, 2H), 7.63 (d, 1H), 8.04 (d, 1H), 7.13 (s, 1H), 7.25 (s, 1H)
	With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80℃; for 2.5h;	5-Bromo-2-fluorobenzaldehyde (25 g) and potassium carbonate (34 g) were suspended in N,N-dimethylformamide (125 ml), and ethyl thioglycolate (14.2 ml) was added dropwise. After being stirred for 30 minutes at room temperature, this was heated for 2 hours at 80C. It was then poured into ice-cooled aqueous citric acid solution and extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The precipitated crystals were filtered out and washed with hexane to obtain ethyl 5-bromo-1-benzothiophen-2-carboxylate (29.2 g) as colorless crystals. 1H-NMR (300MHz, CDC13) 5 1.42 (3H, t, J = 7.2 Hz), 4.41 (2H, q, J = 7.2 Hz), 7.54 (1H, dd, J = 1.7, 8.7 Hz), 7.73 (1H, d, J = 8.7 Hz), 7.97 (1H, s), 8.01 (1H, d, J = 1.7 Hz)
	With sodium carbonate;	Example 218 Synthesis of ethyl 5-bromobenzo[b]thiophene-2-carboxylate. To a solution of 5-bromo-2-fluorobenzaldehyde (2.03 g, 10 mmol) and ethyl 2-mercaptoacetate (1.2 g, 10 mmol) in EtOH (40 mL) was added Na2CO3 (1.27 g, 12 mmol). The reaction mixture was stirred at reflux for 14 h. Then the mixture was concentrated in vacuo. Water (20 mL) was added and the mixture was extracted with DCM (50 mL*3). The combined organic layers were concentrated to give the crude product, which was purified by silica gel chromatography (PE/EtOAc=1/1) to give the ethyl 5-bromobenzo[b]thiophene-2-carboxylate as a yellow solid (2.3 g, yield: 80%). ESI-MS [M+H]+: 284.7, 286.7.

References: [1]RSC Advances,2016,vol. 6,p. 83448 - 83455.
[2]Patent: US2014/303207,2014,A1 .Location in patent: Paragraph 0303-0305.
[3]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 66-67.
[4]Patent: US2019/284182,2019,A1 .

4
[ 13771-68-1 ]
[ 1679-18-1 ]
[ 907945-16-8 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), 4-chlorophenylboronic acid (1.2 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis triphenylphosphine palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate), and the precipitated crystals were filtered out and washed with ethyl acetate-hexane to obtain ethyl 5-(4-chlorophenyl)-1-benzothiophene-2-carboxylate (1.9 g) as colorless crystals. 1H-NMR (300MHz, CDCl3) δ 1.43 (3H, t, J = 7.1 Hz), 4.43 (2H, q, J = 7.1 Hz), 7.52 (2H, d, J = 8.5 Hz), 7.57 (2H, d, J = 8.5 Hz), 7.65 (1H, dd, J = 1.8, 8.6 Hz), 7.93 (1H, d, J = 8.6 Hz), 8.02 (1H, d, J = 1.8 Hz), 8.10 (1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 73.

5
[ 13771-68-1 ]
[ 128796-39-4 ]
[ 907945-18-0 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), 4-trifluoromethylphenylboronic acid (1.47 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis triphenylphosphine palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The precipitated crystals were filtered out and washed with ethyl acetate-hexane to obtain ethyl 5-[4-(trifluoromethyl)phenyl]-1-benzothiophene-2-carboxylate (2.2 g) as colorless crystals. 1H-NMR (300MHz, CDCl3) δ 1.44 (3H, t, J = 7.2 Hz), 4.43 (2H, q, J = 7.2 Hz), 7.70 (1H, dd, J = 1.7, 8.8 Hz), 7.74 (4H, s), 7.96 (1H, d, J = 8.5 Hz), 8.07 (1H, d, J = 1. 7 Hz), 8.12 (1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 73.

6
[ 6165-69-1 ]
[ 13771-68-1 ]
[ 907945-20-4 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), 3-thiopheneboronic acid (0.99 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis triphenylphosphine palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane) to obtain ethyl 5-(3-thienyl)-1-benzothiophene-2-carboxylate (1.9 g) as colorless crystals. 1H-NMR (300MHz, CDCl3) δ 1.43 (3H, t, J = 7.2 Hz), 4.42 (2H, q, J = 7.2 Hz), 7.39-7.49 (2H, m), 7.51-7.52 (1H, m) 7.71(1 H, dd, J = 1.5, 8.5Hz,) 7.88 (1H, d, J = 8.5 Hz), 8.07 (1H, d, J = 1.5 Hz) 8.08 (1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 74.

7
[ 13771-68-1 ]
[ 5720-07-0 ]
[ 907945-22-6 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), 4-methoxyphenylboronic acid (1.2 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis triphenylphosphine palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane) to obtain ethyl 5-(4-methoxyphenyl)-1-benzothiophene-2-carboxylate (1.89 g) as colorless crystals. 1H-NMR (300MHz, CDCl3) δ 1.43 (3H, t, J = 7.2 Hz), 3.87 (3H, s), 4.42 (2H, q, J = 7.2 Hz), 7.01 (2H, d, J = 8.7 Hz), 7. 58 (2H, d, J = 8.7 Hz), 7.66 (1H, dd, J = 1. 7, 8.5 Hz), 7.89 (1H, d, J = 8.5Hz), 8.01 (1H, d, J=1.7Hz), 8.09(1H,s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 74.

8
[ 13771-68-1 ]
[ 78887-39-5 ]
[ 907945-25-9 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), 3-acetamidobenzene boronic acid (1.38 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis triphenylphosphine palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane) to obtain ethyl 5-[3-(acetylamino)phenyl]-1-benzothiophene-2-carboxylate (1.91 g) as pale brown crystals. 1H-NMR (300MHz, CDCl3) δ 1.43 (3H, t, J = 7.1 Hz), 2.22 (3H, s), 4.43 (2H, q, J = 7.1 Hz), 7.34-7.54 (3H, m), 7.69 (1H, dd, J = 1.7, 8.5 Hz), 7.85 (1H, s), 7.91 (1H, d, J = 8.5 Hz), 8.05 (1H, d, J = 1.7Hz), 8.09(1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 75.

9
[ 13771-68-1 ]
[ 1692-25-7 ]
[ 907945-27-1 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), pyridine-3-boronic acid (0.95 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis(triphenylphosphine)palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane) to obtain ethyl 5-(pyridin-3-yl)-1-benzothiophene-2-carboxylate (1.39 g) as pale yellow crystals. 1H-NMR (300MHz, CDCl3) δ 1.44 (3H, t, J = 7.2 Hz), 4.43 (2H, q, J = 7.2 Hz), 7.41 (1H, dd, J = 4.9, 7. 9 Hz), 7.68 (1H, dd, J = 1. 8, 8.6 Hz), 7.90-7.96 (1H, m), 7.97 (1H, d, J = 8.6 Hz), 8.06 (1H, d, J = 1.5 Hz), 8.12 (1H, s), 8.63 (1H, dd, J = 1.5, 4.8 Hz), 8.91 (1H, d, J = 1.8 Hz)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 75.

10
[ 13771-68-1 ]
[ 28611-39-4 ]
[ 907945-29-3 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), 4-dimethylaminophenylboronic acid (1.27 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis(triphenylphosphine)palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane) to obtain ethyl 5-[4-(dimethylamino)phenyl]-1-benzothiophene-2-carboxylate (1.36 g) as yellow crystals. 1H-NMR (300MHz, CDCl3) δ 1.43 (3H, t, J = 7.1 Hz), 3.01 (6H, s), 4.42 (2H, q, J = 7.1 Hz), 6.83 (2H, d, J = 8.9 Hz), 7.65 (2H, d, J = 8.9 Hz), 7.68 (1H, dd, J = 1.7, 8.5 Hz), 7.87 (1H, d, J = 8.5Hz), 8.00 (1H, d, J = 1.7 Hz), 8.08 (1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 75.

11
[ 13771-68-1 ]
[ 1765-93-1 ]
[ 907945-31-7 ]

Yield	Reaction Conditions	Operation in experiment
		Ethyl 5-bromo-1-benzothiophene-2-carboxylate (2.0 g), 4-fluorophenyl boronic acid (1.08 g), 1 M potassium carbonate aqueous solution (15 mL) and ethanol (15 mL) were added to toluene (50 mL), and stirred for 30 minutes at room temperature in an argon atmosphere. Tetrakis(triphenylphosphine)palladium (0.24 g) was added and refluxed for 8 hours. The mixture was extracted with ethyl acetate, the organic layer was washed with water and sodium chloride solution and dried over magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane) to obtain ethyl 5-(4-fluorophenyl)-1-benzothiophene-2-carboxylate (1.79 g) as colorless crystals. 1H-NMR (300MHz, CDCl3) δ 1.43 (3H, t, J = 7.2 Hz), 4.43 (2H, q, J = 7.2 Hz), 7.09-7.23 (2H, m), 7.53-7.71 (3H, m), 7.92 (1H, d, J = 8.5 Hz), 8.01 (1H, d, J = 1.5 Hz), 8.09 (1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 76.
[2]Antibiotics,2022,vol. 11.

12
[ 13771-68-1 ]
[ 153624-46-5 ]
[ 907945-53-3 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; at 150℃; for 0.166667h;Microwaves;	A mixture of the ethyl 5-bromo-1-benzothiophene-2-carboxylate obtained in Reference Example 7 (1.00 g), 4-isopropoxyphenyl boronic acid (2.26 g), tetrakis(triphenylphosphine)palladium (0) (402 mg), 2 M sodium carbonate aqueous solution (3.5 mL) and 1,2-dimethoxyethane (16.5 mL) was exposed to microwaves for 10 minutes at 150C. Water was added to the reaction solution, which was then extracted with ethyl acetate. The extract was washed with saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by basic silica gel column chromatography and recrystallized from ethyl acetate-hexane to obtain ethyl 5-(4-isopropoxyphenyl)-1-benzothiophene-2-carboxylate (0.76 g) as colorless crystals. 1H-NMR (300MHz, CDCl3); δ 1.38 (6H, d, J=6.0Hz), 1.43 (3H, t, J=7.2Hz), 4.42 (2H, q, J=7.2Hz), 4.61 (1H, m), 6.99 (2H, d, J=8.7Hz), 7.56 (2H, d, J=8.7Hz), 7.66 (1H, dd, J=1.5, 8.7Hz), 7.88 (1H, d, J=8.7Hz), 8.00 (1H, d, J=1.5Hz), 8.08 (1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 82-83.

13
[ 13771-68-1 ]
[ 5720-05-8 ]
[ 907945-57-7 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; at 150℃; for 0.166667h;Microwaves;	A mixture of ethyl 5-bromo-1-benzothiophene-2-carboxylate (from Reference Example 7) (1.00 g), 4-methylphenyl boronic acid (1.67 g), tetrakis(triphenylphosphine)palladium (0) (300 mg), 2 M sodium carbonate aqueous solution (3.5 mL) and 1,2-dimethoxyethane (20 mL) was exposed to microwaves for 10 minutes at 150C. Water was added to the reaction solution, which was then extracted with ethyl acetate. The extract was washed with saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography and recrystallized from ethyl acetate-hexane to obtain ethyl 5-(4-methylphenyl)-1-benzothiophene-2-carboxylate (0.67 g) as colorless crystals. 1H-NMR (300MHz, CDCl3); δ 1.43 (3H, t, J=7.2Hz), 2.42 (3H, s), 4.42 (2H, q, J=7.2Hz), 7.28 (2H, d, J=8.1Hz), 7.54 (2H, d, J=8.1Hz), 7.69 (1H, dd, J=1.5, 8.4Hz), 7.90 (1H, d, J=8.4Hz), 8.04 (1H, d, J=1.5Hz), 8.09 (1H, s)

References: [1]Patent: EP1849465,2007,A1 .Location in patent: Page/Page column 84.

14
[ 13771-68-1 ]
[ 50638-17-0 ]

References: [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 457 - 465.
[2]Patent: US2014/303207,2014,A1 .

15
[ 7312-10-9 ]
[ 13771-68-1 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; In ethanol;	e) 6.4 g of 5-bromobenzo[b]thiophene-2-carboxylic acid obtained in the above step d) was suspended in 250 ml of ethanol. With cooling on an ice bath and with stirring, 4.45 g of thionyl chloride was added dropwise to the suspension prepared above, followed by refluxing under heating for 1 hour. With ice cooling, 8.15 g of thionyl chloride was further added dropwise to the resulting mixture, followed by refluxing under heating 2 hours. The resulting reaction solution was concentrated and adjusted to pH 9 with saturated sodium bicarbonate aqueous solution. Crystals thus precipitated were collected by filtration and dried to obtain 7.0 g of ethyl 5-bromobenzo[b]thiophene-2-carboxylate. A portion of the thus obtained compound was recrystallized from methanol to obtain needle crystals. mp: 94-95 C. 1 H-NMR (CDCl3) δ: 1.42 (3H, t, J=7.0Hz), 4.41 (2H, q, J=7.0Hz), 7.54 (1H, dd, J=8.8 and 1.8Hz), 7.73 (1H, d, J=8.8Hz), 7.96 (1H, s), 8.01 (1H, d)
	In methanol; thionyl chloride;	e Synthesis of ethyl 5-bromobenzo[b]thiophene-2-carboxylate: In a 100 ml flask, 1.42 g of 5-bromobenzo[b]thiophene-2-carboxylic acid and 25 ml of methanol were introduced and then stirred. The resulting suspension was cooled in ice bath and 0.6 ml of thionyl chloride was slowly added thereto. The reaction solution was refluxed for one hour and then cooled. After 1.1 ml of thionyl chloride was added, the reaction solution was refluxed for further 2 hours, cooled and then adjusted to pH 9 with saturated NaHCO3 solution. The resulting precipitate was filtered, dried and then purified with silica gel column chromatography [eluent: ethyl acetate/n-hexane(1:3)]. The fractions containing the desired product were combined and then evaporated to obtain 1.3 g of the title compound as a white solid. 1H NMR(CDCl3, ppm): δ 8.01(m, 1H), 7.96(s, 1H), 7.73(m, 1H), 7.54(m, 1H), 4.41(q, 2H, J=7.0 Hz), 1.42(t, 3H, J=7.0 Hz)

References: [1]Patent: US5576343,1996,A .
[2]Patent: US6201006,2001,B1 .

16
[ 13771-68-1 ]
[ 105191-14-8 ]

Yield	Reaction Conditions	Operation in experiment
	In 1-methyl-pyrrolidin-2-one; nitrogen;	f) 7.0 g of <strong>[13771-68-1]ethyl 5-bromobenzo[b]thiophene-2-carboxylate</strong> obtained in the above step e) and 5.4 g of cuprous cyanide were suspended in 70 ml of N-methyl-2-pyrrolidone, and the suspension was stirred for 2 hours with heating at a temperature of 200 C. in a stream of nitrogen. After cooling, the reaction mixture was diluted with ethyl acetate, insoluble materials were removed by filtration, and the resulting filtrate was washed with water and dried. After distilling off the solvent, the crystals precipitated were collected by filtration and washed with ethanol to obtain 5.02 g of ethyl 5-cyanobenzo[b]thiophene-2-carboxylate as crystals. mp: 138-139 C. IR (KBr): 2232, 1728, 1262 cm-1 1 H-NMR (CDCl3) δ: 1.43 (3H, t, J=7.0Hz), 4.45 (2H, q, J=7.0Hz), 7.70 (1H, dd, J=9.0 and 1.8Hz), 8.04 (1H, d, J=9.0Hz), 8.08 (1H), 8.20 (1H)

References: [1]Patent: US5576343,1996,A .

17
[ 13771-68-1 ]
[ 23799-63-5 ]

References: [1]Patent: US2014/303207,2014,A1 .

18
[ 13771-68-1 ]
1-(5-bromobenzo[b]thiophen-2-yl)-2-hydroxymethylcyclopropanecarbonitrile [ No CAS ]

References: [1]Patent: US2014/303207,2014,A1 .

19
[ 13771-68-1 ]
5-(5-bromobenzo[b]thiophen-2-yl)-3-oxabicyclo[3.1.0]hexan-2-one [ No CAS ]

References: [1]Patent: US2014/303207,2014,A1 .

20
[ 13771-68-1 ]
[2-aminomethyl-2-(5-bromobenzo[b]thiophen-2-yl)cyclopropyl]methanol [ No CAS ]