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Chemical Structure| 1365838-67-0 Chemical Structure| 1365838-67-0

Structure of 1365838-67-0

Chemical Structure| 1365838-67-0

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Product Details of [ 1365838-67-0 ]

CAS No. :1365838-67-0
Formula : C9H13ClN4O
M.W : 228.68
SMILES Code : NC1=NC(Cl)=NC(CN2CCOCC2)=C1
MDL No. :MFCD26097276

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Application In Synthesis of [ 1365838-67-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1365838-67-0 ]

[ 1365838-67-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1365838-67-0 ]
  • [ 72605-86-8 ]
  • methyl 2-((2-chloro-6-(morpholinomethyl)pyrimidin-4-yl)amino)thiazole-5-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
A solution of a mixture of 2-chloropyrimidin-4-amine (730 mg, 3.2 mmol) and <strong>[72605-86-8]methyl 2-chlorothiazole-5-carboxylate</strong> (626 mg, 3.5 mmol, 1.1 eq) in dry N,N- dimethylformamide (15 ml) was cooled to 0 C and was treated portionwise over 5 min with sodium hydride (60% w/w in mineral oil, 256 mg, 6.4 mmol, 2 eq). The reaction mixture was stirred at 0 C for 1 h and warmed to ambient temperature for a further 1 h. The mixture was treated with saturated ammonium chloride, followed by saturated aqueous Na2C03 solution to reach pH 9 and the product was extracted with 1 : 1 mixture of dichloromethane and ethyl acetate. The organic extracts were combined, dried using a hydrophobic frit and evaporated under reduced pressure. The residue was purified by chromatography on silica to afford the title compound as an off-white solid. LCMS RT: 2.07 (Method A), Mass m/z 370.37 (M+l).
 

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