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Chemical Structure| 1361054-84-3 Chemical Structure| 1361054-84-3

Structure of 1361054-84-3

Chemical Structure| 1361054-84-3

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Product Details of [ 1361054-84-3 ]

CAS No. :1361054-84-3
Formula : C17H22N2O9S
M.W : 430.43
SMILES Code : O=C(N1[C@H](C(OC)=O)C[C@H](OS(=O)(C2=CC=C([N+]([O-])=O)C=C2)=O)C1)OC(C)(C)C

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Application In Synthesis of [ 1361054-84-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1361054-84-3 ]

[ 1361054-84-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 612501-52-7 ]
  • [ 1361054-84-3 ]
  • [ 612501-71-0 ]
YieldReaction ConditionsOperation in experiment
With cesium fluoride; In N,N-dimethyl-formamide; at 20℃; for 16h; Dimethylformamide (15 ml) was added to 4- (3-chloro-2-fluoroanilino)-7-methoxy-6- hydroxyquinazoline (0.66 g; prepared as described in Example 22-preparation of starting materials), 1-tert-butyl 2-methyl (2S, 4S)-4- [ (4-nitrophenyl) sulfonyloxy] pyrrolidine-1, 2- dicarboxylate (0. 889 g) and cesium fluoride (0.941 g). The reaction mixture was then stirred at room temperature for 16 hours. The reaction mixture was evaporated under vacuum and the residue partitioned between ethyl acetate and water. The organics were washed with water and saturated brine and dried over magnesium sulfate. The product was then purified by column chromatography eluting with increasingly polar mixtures of methylene chloride /methanol (100/0 to 95/5). The fractions containing the expected product were combined and evaporated under vacuum to give 4-(3-chloro-2-fluoroanilino)-6-[(2S, 4R)-l-(t- butoxycarbonyl)-2- (methoxycarbonyl) pyrrolidin-4-yloxy] -7-methoxyquinazoline as a colourless gum (0.36 g); Mass Spectrum: (M+H) + 547.
 

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