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Chemical Structure| 135614-99-2 Chemical Structure| 135614-99-2

Structure of 135614-99-2

Chemical Structure| 135614-99-2

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Product Details of [ 135614-99-2 ]

CAS No. :135614-99-2
Formula : C9H17NO3
M.W : 187.24
SMILES Code : O=C(OC(C)(C)C)N(C)CC1OC1
MDL No. :MFCD24466164

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Application In Synthesis of [ 135614-99-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 135614-99-2 ]

[ 135614-99-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37663-44-8 ]
  • [ 135614-99-2 ]
  • [ 741683-27-2 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 100℃; for 18h; To a solution of tert-butyl N-methyl-N-(2-oxylanylmethyl) carbamate (300 mg) in DMF (3 ml), spiro[isobenzofuran-1(3), 4'-piperidine] hydrochloride (326 mg) and potassium carbonate (332 mg) were added and stirred for 18 hours at 100°C. The reaction liquid was cooled to room temperature and to which water was added, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and condensed under reduced pressure. The resulting residue was purified on silica gel column chromatography (methanol/chloroform = 1/20) to provide tert-butyl N-methyl-N-(2-hydroxy-3-(spiro- [isobenzofuran-1(3H), 4'-piperidin]-1-yl)propyl] carbamate (578 mg) as a pale yellow oily substance.
 

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