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Chemical Structure| 1355592-27-6 Chemical Structure| 1355592-27-6

Structure of 1355592-27-6

Chemical Structure| 1355592-27-6

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Product Details of [ 1355592-27-6 ]

CAS No. :1355592-27-6
Formula : C12H14O3
M.W : 206.24
SMILES Code : O=C(C1=CC=C2CC(O)CCC2=C1)OC
MDL No. :MFCD22572881

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Application In Synthesis of [ 1355592-27-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1355592-27-6 ]

[ 1355592-27-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1355592-27-6 ]
  • [ 19235-88-2 ]
  • [ 1355593-41-7 ]
YieldReaction ConditionsOperation in experiment
95% With caesium carbonate; In 1,4-dioxane; at 100℃; for 24h;Sealed tube; Step 1: methyl 6-[(2-cyanopyridin-4-yl)oxy]-5,6,7,8-tetrahydronaphthalene-2-carboxylate Intermediate 90A mixture of methyl 6-hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylate (0.100 g, 0.48 mmol), 4-nitro-2-pyridinecarbonitrile (0.144 g, 0.969 mmol), cesium carbonate (0.473 g, 1.45 mmol) and 1,4-dioxane (2.00 mL) was heated in a sealed tube at 100 C. for 24 h. Water was added and the mixture was extracted into EtOAc (2×). The organic phases were washed with brine, dried over anhydrous Na2SO4, filtered and evaporated. The residue was purified by silica gel chromatography (0% to 50% EtOAc/hexane) to afford the title compound (142 mg, 95%). LCMS (FA) ES+ 309.
 

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